Short‐ or long‐term high‐fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1

• Published in: Hepatology (Baltimore, Md.) Vol. 62; no. 4; pp. 1070 - 1085
• Main Authors: Chang, Binxia, Xu, Ming‐Jiang, Zhou, Zhou, Cai, Yan, Li, Man, Wang, Wei, Feng, Dechun, Bertola, Adeline, Wang, Hua, Kunos, George, Gao, Bin
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.10.2015
• Subjects: Acute Disease; Animals; Binge Drinking - complications; Chemokine CXCL1 - physiology; Diet, High-Fat - adverse effects; Ethanol - administration & dosage; Fatty acids; Fatty Liver - etiology; Hepatology; Kinases; Liver Diseases - etiology; Liver Diseases - immunology; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Rodents; Time Factors

Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high‐fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge–induced liver neutrophil...