Short‐ or long‐term high‐fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1
Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high‐fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge–induced liver neutrophil...
Saved in:
| Published in | Hepatology (Baltimore, Md.) Vol. 62; no. 4; pp. 1070 - 1085 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wolters Kluwer Health, Inc
01.10.2015
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high‐fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge–induced liver neutrophil infiltration and injury. Feeding mice with an HFD for 3 months plus a single binge of ethanol induced much more severe steatohepatitis. Moreover, 3‐day or 3‐month HFD‐plus‐ethanol binge (3d‐HFD+ethanol or 3m‐HFD+ethanol) treatment markedly up‐regulated the hepatic expression of several chemokines, including chemokine (C‐X‐C motif) ligand 1 (Cxcl1), which showed the highest fold (approximately 20‐fold and 35‐fold, respectively) induction. Serum CXCL1 protein levels were also markedly elevated after the HFD+ethanol treatment. Blockade of CXCL1 with a CXCL1 neutralizing antibody or genetic deletion of the Cxcl1 gene reduced the HFD+ethanol‐induced hepatic neutrophil infiltration and injury, whereas overexpression of Cxcl1 exacerbated steatohepatitis in HFD‐fed mice. Furthermore, expression of Cxcl1 messenger RNA was up‐regulated in hepatocytes, hepatic stellate cells, and endothelial cells isolated from HFD+ethanol‐fed mice compared to mice that were only given the HFD, with the highest fold induction observed in hepatocytes. In vitro stimulation of hepatocytes with palmitic acid up‐regulated the expression of Cxcl1 messenger RNA, and this up‐regulation was attenuated after treatment with an inhibitor of extracellular signal–regulated kinase 1/2, c‐Jun N‐terminal kinase, or nuclear factor κB. In addition, hepatic or serum levels of free fatty acids were higher in HFD+ethanol‐fed mice than in the control groups. Conclusion: An HFD combined with acute ethanol consumption synergistically induces acute liver inflammation and injury through the elevation of hepatic or serum free fatty acids and subsequent up‐regulation of hepatic CXCL1 expression and promotion of hepatic neutrophil infiltration. (Hepatology 2015;62:1070‐1085) |
|---|---|
| AbstractList | Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrated that feeding mice a high-fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge-induced liver neutrophil infiltration and injury. Feeding mice with a HFD for 3 months plus a single binge of ethanol induced much more severe steatohepatitis. Moreover, 3-day or 3-month HFD-plus-ethanol binge (3d-HFD+ethanol or 3m-HFD+ethanol) treatment markedly upregulated the hepatic expression of several chemokines, including chemokine (C-X-C motif) ligand 1 (
Cxcl1
), which showed the highest fold (approximately 20-fold and 35-fold, respectively) induction. Serum CXCL1 protein levels were markedly elevated after the HFD+ethanol treatment. Blockade of CXCL1 with a CXCL1 neutralizing antibody or genetic deletion of the
Cxcl1
gene reduced the HFD+ethanol-induced hepatic neutrophil infiltration and injury; whereas overexpression of the
Cxcl1
exacerbated steatohepatitis in HFD-fed mice. Furthermore, the expression of
Cxcl1
mRNA was upregulated in hepatocytes, hepatic stellate cells and endothelial cells isolated from HFD+ethanol-fed mice compared to mice that were only given a HFD, with the highest fold induction observed in hepatocytes.
In vitro
stimulation of hepatocytes with palmitic acid upregulated the expression of
Cxcl1
mRNA, and this upregulation was attenuated after treatment with ERK1/2, JNK, or NF-κB inhibitors. In addition, hepatic or serum levels of free fatty acids (FFAs) were higher in HFD+ethanol-fed mice than in the control groups.
In conclusion
, a HFD combined with acute ethanol consumption synergistically induces acute liver inflammation and injury via the elevation of hepatic or serum FFAs and subsequent upregulation of hepatic CXCL1 expression and promotion of hepatic neutrophil infiltration. Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high‐fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge–induced liver neutrophil infiltration and injury. Feeding mice with an HFD for 3 months plus a single binge of ethanol induced much more severe steatohepatitis. Moreover, 3‐day or 3‐month HFD‐plus‐ethanol binge (3d‐HFD+ethanol or 3m‐HFD+ethanol) treatment markedly up‐regulated the hepatic expression of several chemokines, including chemokine (C‐X‐C motif) ligand 1 (Cxcl1), which showed the highest fold (approximately 20‐fold and 35‐fold, respectively) induction. Serum CXCL1 protein levels were also markedly elevated after the HFD+ethanol treatment. Blockade of CXCL1 with a CXCL1 neutralizing antibody or genetic deletion of the Cxcl1 gene reduced the HFD+ethanol‐induced hepatic neutrophil infiltration and injury, whereas overexpression of Cxcl1 exacerbated steatohepatitis in HFD‐fed mice. Furthermore, expression of Cxcl1 messenger RNA was up‐regulated in hepatocytes, hepatic stellate cells, and endothelial cells isolated from HFD+ethanol‐fed mice compared to mice that were only given the HFD, with the highest fold induction observed in hepatocytes. In vitro stimulation of hepatocytes with palmitic acid up‐regulated the expression of Cxcl1 messenger RNA, and this up‐regulation was attenuated after treatment with an inhibitor of extracellular signal–regulated kinase 1/2, c‐Jun N‐terminal kinase, or nuclear factor κB. In addition, hepatic or serum levels of free fatty acids were higher in HFD+ethanol‐fed mice than in the control groups. Conclusion: An HFD combined with acute ethanol consumption synergistically induces acute liver inflammation and injury through the elevation of hepatic or serum free fatty acids and subsequent up‐regulation of hepatic CXCL1 expression and promotion of hepatic neutrophil infiltration. (Hepatology 2015;62:1070‐1085) Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high-fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge-induced liver neutrophil infiltration and injury. Feeding mice with an HFD for 3 months plus a single binge of ethanol induced much more severe steatohepatitis. Moreover, 3-day or 3-month HFD-plus-ethanol binge (3d-HFD+ethanol or 3m-HFD+ethanol) treatment markedly up-regulated the hepatic expression of several chemokines, including chemokine (C-X-C motif) ligand 1 (Cxcl1), which showed the highest fold (approximately 20-fold and 35-fold, respectively) induction. Serum CXCL1 protein levels were also markedly elevated after the HFD+ethanol treatment. Blockade of CXCL1 with a CXCL1 neutralizing antibody or genetic deletion of the Cxcl1 gene reduced the HFD+ethanol-induced hepatic neutrophil infiltration and injury, whereas overexpression of Cxcl1 exacerbated steatohepatitis in HFD-fed mice. Furthermore, expression of Cxcl1 messenger RNA was up-regulated in hepatocytes, hepatic stellate cells, and endothelial cells isolated from HFD+ethanol-fed mice compared to mice that were only given the HFD, with the highest fold induction observed in hepatocytes. In vitro stimulation of hepatocytes with palmitic acid up-regulated the expression of Cxcl1 messenger RNA, and this up-regulation was attenuated after treatment with an inhibitor of extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase, or nuclear factor κB. In addition, hepatic or serum levels of free fatty acids were higher in HFD+ethanol-fed mice than in the control groups.UNLABELLEDObesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high-fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge-induced liver neutrophil infiltration and injury. Feeding mice with an HFD for 3 months plus a single binge of ethanol induced much more severe steatohepatitis. Moreover, 3-day or 3-month HFD-plus-ethanol binge (3d-HFD+ethanol or 3m-HFD+ethanol) treatment markedly up-regulated the hepatic expression of several chemokines, including chemokine (C-X-C motif) ligand 1 (Cxcl1), which showed the highest fold (approximately 20-fold and 35-fold, respectively) induction. Serum CXCL1 protein levels were also markedly elevated after the HFD+ethanol treatment. Blockade of CXCL1 with a CXCL1 neutralizing antibody or genetic deletion of the Cxcl1 gene reduced the HFD+ethanol-induced hepatic neutrophil infiltration and injury, whereas overexpression of Cxcl1 exacerbated steatohepatitis in HFD-fed mice. Furthermore, expression of Cxcl1 messenger RNA was up-regulated in hepatocytes, hepatic stellate cells, and endothelial cells isolated from HFD+ethanol-fed mice compared to mice that were only given the HFD, with the highest fold induction observed in hepatocytes. In vitro stimulation of hepatocytes with palmitic acid up-regulated the expression of Cxcl1 messenger RNA, and this up-regulation was attenuated after treatment with an inhibitor of extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase, or nuclear factor κB. In addition, hepatic or serum levels of free fatty acids were higher in HFD+ethanol-fed mice than in the control groups.An HFD combined with acute ethanol consumption synergistically induces acute liver inflammation and injury through the elevation of hepatic or serum free fatty acids and subsequent up-regulation of hepatic CXCL1 expression and promotion of hepatic neutrophil infiltration.CONCLUSIONAn HFD combined with acute ethanol consumption synergistically induces acute liver inflammation and injury through the elevation of hepatic or serum free fatty acids and subsequent up-regulation of hepatic CXCL1 expression and promotion of hepatic neutrophil infiltration. Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high‐fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge–induced liver neutrophil infiltration and injury. Feeding mice with an HFD for 3 months plus a single binge of ethanol induced much more severe steatohepatitis. Moreover, 3‐day or 3‐month HFD‐plus‐ethanol binge (3d‐HFD+ethanol or 3m‐HFD+ethanol) treatment markedly up‐regulated the hepatic expression of several chemokines, including chemokine (C‐X‐C motif) ligand 1 ( Cxcl1 ), which showed the highest fold (approximately 20‐fold and 35‐fold, respectively) induction. Serum CXCL1 protein levels were also markedly elevated after the HFD+ethanol treatment. Blockade of CXCL1 with a CXCL1 neutralizing antibody or genetic deletion of the Cxcl1 gene reduced the HFD+ethanol‐induced hepatic neutrophil infiltration and injury, whereas overexpression of Cxcl1 exacerbated steatohepatitis in HFD‐fed mice. Furthermore, expression of Cxcl1 messenger RNA was up‐regulated in hepatocytes, hepatic stellate cells, and endothelial cells isolated from HFD+ethanol‐fed mice compared to mice that were only given the HFD, with the highest fold induction observed in hepatocytes. In vitro stimulation of hepatocytes with palmitic acid up‐regulated the expression of Cxcl1 messenger RNA, and this up‐regulation was attenuated after treatment with an inhibitor of extracellular signal–regulated kinase 1/2, c‐Jun N‐terminal kinase, or nuclear factor κB. In addition, hepatic or serum levels of free fatty acids were higher in HFD+ethanol‐fed mice than in the control groups. Conclusion : An HFD combined with acute ethanol consumption synergistically induces acute liver inflammation and injury through the elevation of hepatic or serum free fatty acids and subsequent up‐regulation of hepatic CXCL1 expression and promotion of hepatic neutrophil infiltration. (H epatology 2015;62:1070‐1085) Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high-fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge-induced liver neutrophil infiltration and injury. Feeding mice with an HFD for 3 months plus a single binge of ethanol induced much more severe steatohepatitis. Moreover, 3-day or 3-month HFD-plus-ethanol binge (3d-HFD+ethanol or 3m-HFD+ethanol) treatment markedly up-regulated the hepatic expression of several chemokines, including chemokine (C-X-C motif) ligand 1 (Cxcl1), which showed the highest fold (approximately 20-fold and 35-fold, respectively) induction. Serum CXCL1 protein levels were also markedly elevated after the HFD+ethanol treatment. Blockade of CXCL1 with a CXCL1 neutralizing antibody or genetic deletion of the Cxcl1 gene reduced the HFD+ethanol-induced hepatic neutrophil infiltration and injury, whereas overexpression of Cxcl1 exacerbated steatohepatitis in HFD-fed mice. Furthermore, expression of Cxcl1 messenger RNA was up-regulated in hepatocytes, hepatic stellate cells, and endothelial cells isolated from HFD+ethanol-fed mice compared to mice that were only given the HFD, with the highest fold induction observed in hepatocytes. In vitro stimulation of hepatocytes with palmitic acid up-regulated the expression of Cxcl1 messenger RNA, and this up-regulation was attenuated after treatment with an inhibitor of extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase, or nuclear factor [kappa]B. In addition, hepatic or serum levels of free fatty acids were higher in HFD+ethanol-fed mice than in the control groups. Conclusion: An HFD combined with acute ethanol consumption synergistically induces acute liver inflammation and injury through the elevation of hepatic or serum free fatty acids and subsequent up-regulation of hepatic CXCL1 expression and promotion of hepatic neutrophil infiltration. (Hepatology 2015;62:1070-1085) Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we demonstrate that feeding mice a high-fat diet (HFD) for as little as 3 days markedly exacerbated acute ethanol binge-induced liver neutrophil infiltration and injury. Feeding mice with an HFD for 3 months plus a single binge of ethanol induced much more severe steatohepatitis. Moreover, 3-day or 3-month HFD-plus-ethanol binge (3d-HFD+ethanol or 3m-HFD+ethanol) treatment markedly up-regulated the hepatic expression of several chemokines, including chemokine (C-X-C motif) ligand 1 (Cxcl1), which showed the highest fold (approximately 20-fold and 35-fold, respectively) induction. Serum CXCL1 protein levels were also markedly elevated after the HFD+ethanol treatment. Blockade of CXCL1 with a CXCL1 neutralizing antibody or genetic deletion of the Cxcl1 gene reduced the HFD+ethanol-induced hepatic neutrophil infiltration and injury, whereas overexpression of Cxcl1 exacerbated steatohepatitis in HFD-fed mice. Furthermore, expression of Cxcl1 messenger RNA was up-regulated in hepatocytes, hepatic stellate cells, and endothelial cells isolated from HFD+ethanol-fed mice compared to mice that were only given the HFD, with the highest fold induction observed in hepatocytes. In vitro stimulation of hepatocytes with palmitic acid up-regulated the expression of Cxcl1 messenger RNA, and this up-regulation was attenuated after treatment with an inhibitor of extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase, or nuclear factor κB. In addition, hepatic or serum levels of free fatty acids were higher in HFD+ethanol-fed mice than in the control groups. An HFD combined with acute ethanol consumption synergistically induces acute liver inflammation and injury through the elevation of hepatic or serum free fatty acids and subsequent up-regulation of hepatic CXCL1 expression and promotion of hepatic neutrophil infiltration. |
| Author | Zhou, Zhou Cai, Yan Wang, Wei Chang, Binxia Bertola, Adeline Li, Man Gao, Bin Feng, Dechun Wang, Hua Xu, Ming‐Jiang Kunos, George |
| AuthorAffiliation | 3 Diagnosis and Treatment Center for Non-Infectious Liver Diseases, Institute of Alcoholic Liver Disease, Beijing 302 Hospital, Beijing 1 Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA 2 Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA |
| AuthorAffiliation_xml | – name: 1 Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA – name: 3 Diagnosis and Treatment Center for Non-Infectious Liver Diseases, Institute of Alcoholic Liver Disease, Beijing 302 Hospital, Beijing – name: 2 Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA |
| Author_xml | – sequence: 1 givenname: Binxia surname: Chang fullname: Chang, Binxia organization: Institute of Alcoholic Liver Disease – sequence: 2 givenname: Ming‐Jiang surname: Xu fullname: Xu, Ming‐Jiang organization: National Institutes of Health – sequence: 3 givenname: Zhou surname: Zhou fullname: Zhou, Zhou organization: National Institutes of Health – sequence: 4 givenname: Yan surname: Cai fullname: Cai, Yan organization: National Institutes of Health – sequence: 5 givenname: Man surname: Li fullname: Li, Man organization: National Institutes of Health – sequence: 6 givenname: Wei surname: Wang fullname: Wang, Wei organization: National Institutes of Health – sequence: 7 givenname: Dechun surname: Feng fullname: Feng, Dechun organization: National Institutes of Health – sequence: 8 givenname: Adeline surname: Bertola fullname: Bertola, Adeline organization: National Institutes of Health – sequence: 9 givenname: Hua surname: Wang fullname: Wang, Hua organization: National Institutes of Health – sequence: 10 givenname: George surname: Kunos fullname: Kunos, George organization: National Institutes of Health – sequence: 11 givenname: Bin surname: Gao fullname: Gao, Bin organization: National Institutes of Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26033752$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNks2KFDEQx4OsuLOrB19AAl700Lv56J50e1hYhtUVBhRU8BYy6erpDOlkTNIrc_MRvPl-PolpZ1Z0UZBAUlT96l-VpE7QkfMOEHpMyRklhJ33sD1jomH0HprRiomC84ocoRlhghQN5c0xOolxQwhpSlY_QMdsTjgXFZuhb-96H9L3L1-xD9h6t85mgjDg3qz7bHcq4dZAwh1Aa9wab-0YsdJjAgypV85bvMp-wHHnIKxNTEYra3fYuHbUcECtuYGQXZsxTBE8GA0v8KXDZtjm-solHLwF3OUuFh8XS_oQ3e-UjfDocJ6iDy-v3i-ui-WbV68Xl8tCV0LQQnTQKcVr3lTlKi-glNet6tqyVRrmc1IyTVjNiO7Kti6btuJaQQ1McxC6KvkputjrbsfVAK0Gl4KychvMoMJOemXknxFnern2N7Ks6qYseRZ4dhAI_tMIMcnBRA3WKgd-jJIKxqiYtv9Aac05EXRCn95BN34MLr_ERAlWz7Nmpp783vyvrm-_NwPne0AHH2OATmqTVDJ-uouxkhI5DZDMAyR_DlDOeH4n41b0b-xB_bOxsPs3KK-v3u4zfgCKSNma |
| CODEN | HPTLD9 |
| CitedBy_id | crossref_primary_10_1002_hep_31031 crossref_primary_10_1136_gutjnl_2024_332514 crossref_primary_10_1038_s41575_021_00444_2 crossref_primary_10_1038_s41598_018_31025_0 crossref_primary_10_1016_j_livres_2024_06_001 crossref_primary_10_1172_JCI157780 crossref_primary_10_1002_hep_31390 crossref_primary_10_1016_j_jcmgh_2018_12_009 crossref_primary_10_1016_j_jhepr_2024_101250 crossref_primary_10_3390_cells13110960 crossref_primary_10_1053_j_gastro_2016_02_035 crossref_primary_10_1016_j_molmet_2023_101813 crossref_primary_10_4254_wjh_v7_i27_2703 crossref_primary_10_1038_nrgastro_2017_116 crossref_primary_10_1007_s10238_024_01305_3 crossref_primary_10_1002_hep4_1129 crossref_primary_10_3390_biom12081035 crossref_primary_10_1016_j_jcmgh_2016_12_004 crossref_primary_10_3389_fphys_2021_691738 crossref_primary_10_2174_1570163817666200121143959 crossref_primary_10_1021_acs_jafc_9b07368 crossref_primary_10_1016_j_metabol_2024_155942 crossref_primary_10_1016_j_jcmgh_2022_10_002 crossref_primary_10_1177_0271678X17744718 crossref_primary_10_1002_hep_29129 crossref_primary_10_1055_a_2145_7331 crossref_primary_10_1016_j_tma_2024_01_001 crossref_primary_10_26599_FSHW_2024_9250031 crossref_primary_10_3390_diseases12040069 crossref_primary_10_3390_ijms19041145 crossref_primary_10_3389_fphar_2022_895710 crossref_primary_10_3390_medicina58060761 crossref_primary_10_3390_livers1010003 crossref_primary_10_1111_1440_1681_12976 crossref_primary_10_1016_j_ajpath_2024_11_011 crossref_primary_10_1016_j_kint_2019_10_024 crossref_primary_10_1111_acer_14220 crossref_primary_10_1111_acer_14065 crossref_primary_10_1016_j_jcmgh_2024_04_009 crossref_primary_10_1136_gutjnl_2023_331447 crossref_primary_10_1177_09731296221144812 crossref_primary_10_3389_fmed_2023_1160053 crossref_primary_10_1038_s41423_020_00560_0 crossref_primary_10_1039_D0FO02653K crossref_primary_10_3389_fimmu_2021_625472 crossref_primary_10_1016_j_livres_2019_04_002 crossref_primary_10_1053_j_gastro_2019_03_013 crossref_primary_10_1152_ajpgi_00281_2023 crossref_primary_10_3390_ijms241914564 crossref_primary_10_1155_2018_9630175 crossref_primary_10_1152_ajpgi_00217_2019 crossref_primary_10_1055_s_0044_1789207 crossref_primary_10_3390_genes14030693 crossref_primary_10_1155_2023_4399998 crossref_primary_10_1016_S1875_5364_20_30018_2 crossref_primary_10_1186_s12950_022_00321_y crossref_primary_10_1002_adma_201707443 crossref_primary_10_1007_s12272_025_01537_1 crossref_primary_10_1016_j_jhep_2018_10_023 crossref_primary_10_1097_HC9_0000000000000174 crossref_primary_10_1186_s13287_017_0524_3 crossref_primary_10_1136_jim_2016_000204 crossref_primary_10_1242_dmm_046383 crossref_primary_10_3390_cells10123333 crossref_primary_10_1093_toxres_tfab042 crossref_primary_10_1016_j_livres_2018_02_005 crossref_primary_10_1016_j_pharmthera_2017_06_007 crossref_primary_10_3390_nu13103427 crossref_primary_10_1155_2018_1509851 crossref_primary_10_1538_expanim_22_0160 crossref_primary_10_1016_j_jhep_2020_04_011 crossref_primary_10_1016_j_livres_2018_02_002 crossref_primary_10_1172_JCI171691 crossref_primary_10_1097_HC9_0000000000000459 crossref_primary_10_1002_jcp_27634 crossref_primary_10_1038_s41419_025_07376_8 crossref_primary_10_1016_j_obmed_2024_100551 crossref_primary_10_1080_10408398_2023_2214208 crossref_primary_10_1172_JCI176345 crossref_primary_10_1002_jcp_27293 crossref_primary_10_1016_j_ajpath_2015_12_003 crossref_primary_10_3389_fendo_2023_1148827 crossref_primary_10_1186_s13578_020_00507_y crossref_primary_10_1097_HC9_0000000000000200 crossref_primary_10_1038_s41467_021_24843_w crossref_primary_10_3389_fmicb_2020_01159 crossref_primary_10_1016_j_alcohol_2020_08_007 crossref_primary_10_3390_ijms23137151 crossref_primary_10_1007_s40139_017_0141_y crossref_primary_10_1016_j_jcmgh_2021_08_002 crossref_primary_10_3727_105221617X695519 crossref_primary_10_3390_ijms21249407 crossref_primary_10_1055_a_2128_5907 crossref_primary_10_1136_gutjnl_2019_319720 crossref_primary_10_1093_gastro_goad074 crossref_primary_10_3390_cancers9100130 crossref_primary_10_1002_JLB_3AB0820_092RR crossref_primary_10_1007_s00109_022_02196_1 crossref_primary_10_1053_j_gastro_2016_01_025 crossref_primary_10_1016_j_heliyon_2024_e25485 crossref_primary_10_1016_j_cld_2024_06_002 crossref_primary_10_1002_hep_32675 crossref_primary_10_1097_HC9_0000000000000566 crossref_primary_10_1172_jci_insight_92634 crossref_primary_10_1371_journal_pone_0227637 crossref_primary_10_1093_nutrit_nuab031 crossref_primary_10_1097_HEP_0000000000000207 crossref_primary_10_1016_j_livres_2022_09_004 crossref_primary_10_3389_fendo_2021_751802 crossref_primary_10_1038_s41419_018_0720_9 crossref_primary_10_3389_fmed_2021_657076 crossref_primary_10_1016_j_jcmgh_2018_01_009 crossref_primary_10_1016_j_jhep_2023_05_017 crossref_primary_10_3748_wjg_v25_i36_5434 crossref_primary_10_1152_ajpgi_00066_2019 crossref_primary_10_1016_j_lfs_2021_119268 crossref_primary_10_1016_j_chom_2016_01_003 crossref_primary_10_1016_j_tem_2022_07_001 crossref_primary_10_3390_jpm11040287 crossref_primary_10_3892_ijmm_2018_3527 crossref_primary_10_4331_wjbc_v12_i5_87 crossref_primary_10_1016_j_bcp_2018_12_005 crossref_primary_10_1186_s40200_017_0297_3 crossref_primary_10_1093_alcalc_agaa085 crossref_primary_10_1093_lifemeta_loac006 crossref_primary_10_1016_j_jhep_2021_02_028 crossref_primary_10_1111_acer_14700 crossref_primary_10_1111_jpn_13032 crossref_primary_10_1007_s11154_023_09800_w crossref_primary_10_1016_j_jcmgh_2018_01_003 crossref_primary_10_1021_acs_jmedchem_2c01918 crossref_primary_10_1371_journal_pone_0249316 crossref_primary_10_3390_biom8010003 crossref_primary_10_1097_HEP_0000000000000433 crossref_primary_10_1007_s00535_025_02240_0 crossref_primary_10_1016_j_alcohol_2021_10_003 crossref_primary_10_1016_j_pharep_2019_07_002 crossref_primary_10_1093_toxres_tfad033 crossref_primary_10_1038_cmi_2015_97 crossref_primary_10_1111_liv_13482 crossref_primary_10_3390_nu10111665 crossref_primary_10_1016_j_mce_2024_112448 crossref_primary_10_1002_hep_30952 crossref_primary_10_1186_s12944_022_01654_6 crossref_primary_10_3390_nu13051592 crossref_primary_10_1016_j_livres_2018_03_001 crossref_primary_10_1016_j_jhep_2017_11_006 crossref_primary_10_3350_cmh_2020_0100 crossref_primary_10_1360_TB_2022_1202 crossref_primary_10_1002_hep_28530 crossref_primary_10_1186_s13287_024_03995_8 crossref_primary_10_1371_journal_pone_0211703 crossref_primary_10_1002_hep4_1698 crossref_primary_10_3390_ijms23031062 crossref_primary_10_1016_j_jhep_2016_10_023 crossref_primary_10_3389_fimmu_2023_1287136 crossref_primary_10_3390_ijms21103732 crossref_primary_10_1097_HC9_0000000000000257 crossref_primary_10_1371_journal_pone_0164186 |
| Cites_doi | 10.1146/annurev.immunol.18.1.217 10.1177/153537020523000809 10.1074/jbc.M112.371807 10.1096/fj.02-0757fje 10.1016/S1542-3565(05)00743-3 10.1093/ajcn/88.4.1097 10.1053/j.gastro.2010.04.041 10.1002/hep.510250322 10.1172/JCI28898 10.1002/hep.26419 10.1152/ajpgi.1995.269.4.G518 10.1097/MEG.0b013e3283328b86 10.1038/nri3399 10.1146/annurev.immunol.24.021605.090529 10.1002/hep.1840060503 10.1152/ajpgi.00317.2004 10.1016/j.jhep.2010.12.034 10.1002/hep.21175 10.1038/cmi.2014.2 10.1152/ajpendo.00179.2013 10.1111/j.1530-0277.2011.01472.x 10.1371/journal.pone.0080848 10.1002/hep.510250120 10.1111/j.1530-0277.2012.01927.x 10.1002/hep.24552 10.1152/ajpgi.00309.2012 10.1093/cvr/cvq040 10.1053/j.gastro.2014.06.043 10.1016/j.taap.2014.01.004 10.1053/j.gastro.2009.01.056 10.4049/jimmunol.162.5.3031 10.1152/ajpgi.1998.275.4.G847 10.1111/j.1365-2036.2009.04141.x 10.1093/ajcn/47.2.235 10.3109/03602532.2011.645579 10.1371/journal.pone.0013577 10.1189/jlb.0603297 10.1002/hep.21752 10.1161/ATVBAHA.109.194050 10.1016/S0741-8329(02)00200-8 10.1002/hep.510270441 10.1002/hep.20949 10.1002/hep.25801 10.2337/db11-0194 10.3748/wjg.v10.i16.2423 10.1136/gutjnl-2011-300269 10.1177/1753425908088724 10.1016/j.alcohol.2006.12.006 10.1136/bmj.c1240 |
| ContentType | Journal Article |
| Copyright | Published 2015. This article is a U.S. Government work and is in the public domain in the USA. 2015 by the American Association for the Study of Liver Diseases |
| Copyright_xml | – notice: Published 2015. This article is a U.S. Government work and is in the public domain in the USA. – notice: 2015 by the American Association for the Study of Liver Diseases |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 7TM 7TO 7U9 H94 K9. 7X8 5PM |
| DOI | 10.1002/hep.27921 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef AIDS and Cancer Research Abstracts MEDLINE AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1527-3350 |
| EndPage | 1085 |
| ExternalDocumentID | PMC4589443 3821008721 26033752 10_1002_hep_27921 HEP27921 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Intramural |
| GrantInformation_xml | – fundername: Intramural NIH HHS grantid: Z01 AA000369 – fundername: Intramural NIH HHS grantid: Z01 AA000368 |
| GroupedDBID | --- --K .3N .55 .GA .GJ .Y3 05W 0R~ 10A 186 1B1 1CY 1L6 1OB 1OC 1ZS 1~5 24P 31~ 33P 3O- 3SF 3WU 4.4 4G. 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5RE 5VS 7-5 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEDT AAESR AAEVG AAHHS AALRI AANHP AAONW AAQFI AAQQT AAQXK AASGY AAXRX AAXUO AAZKR ABCQN ABCUV ABEML ABIJN ABLJU ABMAC ABOCM ABPVW ABWVN ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACLDA ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADEOM ADIZJ ADKYN ADMGS ADMUD ADNMO ADOZA ADXAS ADZMN ADZOD AECAP AEEZP AEIMD AENEX AEQDE AEUQT AFBPY AFFNX AFGKR AFPWT AFUWQ AFZJQ AHMBA AIACR AIURR AIWBW AJAOE AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BAWUL BDRZF BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EBS EJD F00 F01 F04 F5P FD8 FDB FEDTE FGOYB FUBAC G-S G.N GNP GODZA H.X HBH HF~ HHY HHZ HVGLF HZ~ IHE IX1 J0M J5H JPC KBYEO KQQ LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M41 M65 MJL MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N4W N9A NF~ NNB NQ- O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K R2- RGB RIG RIWAO RJQFR ROL RPZ RWI RX1 RYL SEW SSZ SUPJJ TEORI UB1 V2E V9Y W2D W8V W99 WBKPD WH7 WHWMO WIB WIH WIJ WIK WIN WJL WOHZO WQJ WRC WUP WVDHM WXI X7M XG1 XV2 ZGI ZXP ZZTAW ~IA ~WT AAYXX ABJNI ACZKN AFNMH AGQPQ AHQVU CITATION MEWTI WXSBR AAMMB AEFGJ AGXDD AIDQK AIDYY CGR CUY CVF ECM EIF NPM 7T5 7TM 7TO 7U9 ADSXY H94 K9. 7X8 5PM |
| ID | FETCH-LOGICAL-c5771-7fefaa383954b4b4e1138dafd4dace66042c02820cf4d849d53cae8e2c3e7c543 |
| IEDL.DBID | DR2 |
| ISSN | 0270-9139 1527-3350 |
| IngestDate | Thu Aug 21 13:59:33 EDT 2025 Fri Jul 11 00:32:02 EDT 2025 Tue Aug 05 11:16:36 EDT 2025 Wed Aug 13 04:51:47 EDT 2025 Mon Jul 21 05:57:34 EDT 2025 Thu Apr 24 23:07:11 EDT 2025 Tue Jul 01 03:33:42 EDT 2025 Wed Jan 22 16:21:05 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | Published 2015. This article is a U.S. Government work and is in the public domain in the USA. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5771-7fefaa383954b4b4e1138dafd4dace66042c02820cf4d849d53cae8e2c3e7c543 |
| Notes | These authors contributed equally to this work. Potential conflict of interest: Nothing to report. Supported by the intramural program of the National Institute on Alcohol Abuse and Alcoholism (National Institutes of Health) and by Beijing 302 Hospital (B.C.). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Dr. Binxia Chang and Dr. Ming-Jiang Xu contributed equally to this work. |
| PMID | 26033752 |
| PQID | 1717286177 |
| PQPubID | 996352 |
| PageCount | 16 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4589443 proquest_miscellaneous_1722177221 proquest_miscellaneous_1718330711 proquest_journals_1717286177 pubmed_primary_26033752 crossref_citationtrail_10_1002_hep_27921 crossref_primary_10_1002_hep_27921 wiley_primary_10_1002_hep_27921_HEP27921 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | October 2015 |
| PublicationDateYYYYMMDD | 2015-10-01 |
| PublicationDate_xml | – month: 10 year: 2015 text: October 2015 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Hepatology (Baltimore, Md.) |
| PublicationTitleAlternate | Hepatology |
| PublicationYear | 2015 |
| Publisher | Wolters Kluwer Health, Inc |
| Publisher_xml | – name: Wolters Kluwer Health, Inc |
| References | 2012; 61 2012; 287 2011; 60 2011; 55 1999; 162 2010; 340 2011; 54 2003; 17 2013; 8 1998; 275 2012; 56 2010; 22 2004; 75 2000; 18 2013; 58 2013; 13 1988; 47 1986; 6 2010; 5 2014; 11 2007; 25 1998; 27 2005; 230 1997; 25 2013; 305 2013; 304 2008; 14 2005; 42 2011; 35 2006; 116 2014; 275 2009; 136 2009; 29 2004; 10 2002; 27 2010; 86 2013; 37 2009; 30 2006; 40 2006; 43 2005; 288 2010; 139 1995; 269 2008; 88 2015 2005; 3 2012; 44 2014; 147 2007; 46 (hep27921-bib-0040-20241017) 2010; 139 (hep27921-bib-0041-20241017) 1999; 162 (hep27921-bib-0010-20241017) 2011; 35 (hep27921-bib-0021-20241017) 2014; 147 (hep27921-bib-0044-20241017) 2015 (hep27921-bib-0020-20241017) 2013; 13 (hep27921-bib-0017-20241017) 2011; 60 (hep27921-bib-0045-20241017) 2007; 25 (hep27921-bib-0002-20241017) 1988; 47 (hep27921-bib-0025-20241017) 2008; 14 (hep27921-bib-0047-20241017) 2003; 17 (hep27921-bib-0038-20241017) 2002; 27 (hep27921-bib-0023-20241017) 2009; 136 (hep27921-bib-0001-20241017) 1997; 25 (hep27921-bib-0015-20241017) 2013; 304 (hep27921-bib-0016-20241017) 2012; 287 (hep27921-bib-0007-20241017) 2010; 22 (hep27921-bib-0031-20241017) 2009; 29 (hep27921-bib-0013-20241017) 2011; 55 (hep27921-bib-0029-20241017) 2007; 46 (hep27921-bib-0049-20241017) 1997; 25 (hep27921-bib-0034-20241017) 2014; 275 (hep27921-bib-0032-20241017) 2005; 230 (hep27921-bib-0037-20241017) 2006; 43 (hep27921-bib-0026-20241017) 2004; 75 (hep27921-bib-0022-20241017) 2000; 18 (hep27921-bib-0004-20241017) 2004; 10 (hep27921-bib-0043-20241017) 2012; 61 (hep27921-bib-0046-20241017) 1998; 27 (hep27921-bib-0012-20241017) 1986; 6 (hep27921-bib-0036-20241017) 2012; 44 (hep27921-bib-0030-20241017) 2006; 116 (hep27921-bib-0048-20241017) 2005; 288 (hep27921-bib-0050-20241017) 2010; 5 (hep27921-bib-0009-20241017) 2010; 340 (hep27921-bib-0033-20241017) 2014; 11 (hep27921-bib-0006-20241017) 2008; 88 (hep27921-bib-0039-20241017) 2013; 58 (hep27921-bib-0024-20241017) 2013; 8 (hep27921-bib-0014-20241017) 2005; 42 (hep27921-bib-0035-20241017) 2012; 56 (hep27921-bib-0019-20241017) 2010; 86 (hep27921-bib-0027-20241017) 1998; 275 (hep27921-bib-0005-20241017) 2005; 3 (hep27921-bib-0011-20241017) 2006; 40 (hep27921-bib-0028-20241017) 1995; 269 (hep27921-bib-0003-20241017) 2013; 37 (hep27921-bib-0018-20241017) 2013; 305 (hep27921-bib-0008-20241017) 2009; 30 (hep27921-bib-0042-20241017) 2011; 54 |
| References_xml | – volume: 46 start-page: 823 year: 2007 end-page: 830 article-title: Palmitic acid induces production of proinflammatory cytokine interleukin‐8 from hepatocytes publication-title: Hepatology – volume: 25 start-page: 624 year: 1997 end-page: 630 article-title: Adenovirus‐mediated expression of cytokine‐induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis publication-title: Hepatology – volume: 60 start-page: 2474 year: 2011 end-page: 2483 article-title: Inflammation is necessary for long‐term but not short‐term high‐fat diet‐induced insulin resistance publication-title: Diabetes – volume: 304 start-page: G38 year: 2013 end-page: G47 article-title: Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice publication-title: Am J Physiol Gastrointest Liver Physiol – volume: 5 start-page: e13577 year: 2010 article-title: Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients publication-title: PLoS One – volume: 147 start-page: 577 year: 2014 end-page: 594 article-title: Roles for chemokines in liver disease publication-title: Gastroenterology – volume: 27 start-page: 1172 year: 1998 end-page: 1177 article-title: Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein‐2 and KC publication-title: Hepatology – volume: 86 start-page: 183 year: 2010 end-page: 191 article-title: Molecular regulators of leucocyte chemotaxis during inflammation publication-title: Cardiovasc Res – volume: 14 start-page: 117 year: 2008 end-page: 124 article-title: Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO‐alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)‐induced colitis publication-title: Innate Immun – volume: 17 start-page: 1168 year: 2003 end-page: 1170 article-title: CINC‐1 is an acute‐phase protein induced by focal brain injury causing leukocyte mobilization and liver injury publication-title: FASEB J – volume: 22 start-page: 820 year: 2010 end-page: 825 article-title: A cohort study of the effect of alcohol consumption and obesity on serum liver enzyme levels publication-title: Eur J Gastroenterol Hepatol – volume: 40 start-page: 185 year: 2006 end-page: 191 article-title: Combined effects of high‐fat diet and ethanol induce oxidative stress in rat liver publication-title: Alcohol – volume: 230 start-page: 573 year: 2005 end-page: 586 article-title: Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils publication-title: Exp Biol Med (Maywood) – volume: 288 start-page: G880 year: 2005 end-page: G886 article-title: Generation and functional significance of CXC chemokines for neutrophil‐induced liver injury during endotoxemia publication-title: Am J Physiol Gastrointest Liver Physiol – volume: 29 start-page: 1944 year: 2009 end-page: 1949 article-title: Saturated fatty acids do not directly stimulate Toll‐like receptor signaling publication-title: Arterioscler Thromb Vasc Biol – volume: 18 start-page: 217 year: 2000 end-page: 242 article-title: The biology of chemokines and their receptors publication-title: Annu Rev Immunol – volume: 275 start-page: 122 year: 2014 end-page: 133 article-title: Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans publication-title: Toxicol Appl Pharmacol – volume: 43 start-page: 1220 year: 2006 end-page: 1230 article-title: Neutrophil depletion protects against murine acetaminophen hepatotoxicity publication-title: Hepatology – volume: 58 start-page: 1814 year: 2013 end-page: 1823 article-title: Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E‐selectin publication-title: Hepatology – volume: 61 start-page: 1058 year: 2012 end-page: 1067 article-title: Toll‐like receptor‐4 mediates obesity‐induced non‐alcoholic steatohepatitis through activation of X‐box binding protein‐1 in mice publication-title: Gut – volume: 56 start-page: 1971 year: 2012 end-page: 1982 article-title: Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure publication-title: Hepatology – volume: 8 start-page: e80848 year: 2013 article-title: Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent publication-title: PLoS One – volume: 13 start-page: 159 year: 2013 end-page: 175 article-title: Neutrophil recruitment and function in health and inflammation publication-title: Nat Rev Immunol – volume: 44 start-page: 107 year: 2012 end-page: 115 article-title: Role of immune reactions in drug‐induced liver injury (DILI) publication-title: Drug Metab Rev – volume: 37 start-page: 332 year: 2013 end-page: 338 article-title: Body fat distribution and risk factors for fibrosis in patients with alcoholic liver disease publication-title: Alcohol Clin Exp Res – volume: 27 start-page: 23 year: 2002 end-page: 27 article-title: Neutrophil‐mediated tissue injury in alcoholic hepatitis publication-title: Alcohol – volume: 10 start-page: 2423 year: 2004 end-page: 2426 article-title: Risk factors for alcoholic liver disease in China publication-title: World J Gastroenterol – volume: 340 start-page: c1240 year: 2010 article-title: Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies publication-title: BMJ – volume: 139 start-page: 664 year: 2010 end-page: 674 article-title: Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol‐induced liver injury in mice publication-title: Gastroenterology – volume: 55 start-page: 673 year: 2011 end-page: 682 article-title: Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p‐AMPK publication-title: J Hepatol – volume: 30 start-page: 1137 year: 2009 end-page: 1149 article-title: Synergistic association between alcohol intake and body mass index with serum alanine and aspartate aminotransferase levels in older adults: the Rancho Bernardo Study publication-title: Aliment Pharmacol Ther – volume: 305 start-page: E388 year: 2013 end-page: E395 article-title: Adipose tissue inflammation contributes to short‐term high‐fat diet‐induced hepatic insulin resistance publication-title: Am J Physiol Endocrinol Metab – volume: 275 start-page: G847 year: 1998 end-page: G853 article-title: Rat hepatic stellate cells produce cytokine‐induced neutrophil chemoattractant in culture and in vivo publication-title: Am J Physiol Gastrointest Liver Physiol – year: 2015 article-title: TLR2 and TLR9 contribute to alcohol‐mediated liver injury through induction of CXCL1 and neutrophil infiltration publication-title: Am J Physiol Gastrointest Liver Physiol – volume: 25 start-page: 787 year: 2007 end-page: 820 article-title: Chemokine: receptor structure, interactions, and antagonism publication-title: Annu Rev Immunol – volume: 287 start-page: 24378 year: 2012 end-page: 24386 article-title: Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin‐4 publication-title: J Biol Chem – volume: 162 start-page: 3031 year: 1999 end-page: 3036 article-title: Ethanol‐induced macrophage apoptosis: the role of TGF‐beta publication-title: J Immunol – volume: 25 start-page: 108 year: 1997 end-page: 111 article-title: Excess weight risk factor for alcoholic liver disease publication-title: Hepatology – volume: 35 start-page: 1361 year: 2011 end-page: 1367 article-title: A new model of interactive effects of alcohol and high‐fat diet on hepatic fibrosis publication-title: Alcohol Clin Exp Res – volume: 11 start-page: 224 year: 2014 end-page: 231 article-title: The role of neutrophils in the development of liver diseases publication-title: Cell Mol Immunol – volume: 75 start-page: 443 year: 2004 end-page: 452 article-title: Critical role of CXC chemokines in endotoxemic liver injury in mice publication-title: J Leukoc Biol – volume: 47 start-page: 235 year: 1988 end-page: 238 article-title: Overweight as a risk factor or a predictive sign of histological liver damage in alcoholics publication-title: Am J Clin Nutr – volume: 88 start-page: 1097 year: 2008 end-page: 1103 article-title: Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index publication-title: Am J Clin Nutr – volume: 6 start-page: 814 year: 1986 end-page: 822 article-title: Ethanol‐induced liver fibrosis in rats fed high fat diet publication-title: Hepatology – volume: 116 start-page: 3015 year: 2006 end-page: 3025 article-title: TLR4 links innate immunity and fatty acid‐induced insulin resistance publication-title: J Clin Invest – volume: 42 start-page: 1280 year: 2005 end-page: 1290 article-title: Alcohol increases tumor necrosis factor alpha and decreases nuclear factor‐kappaB to activate hepatic apoptosis in genetically obese mice publication-title: Hepatology – volume: 269 start-page: G518 year: 1995 end-page: G523 article-title: Rat hepatocytes and Kupffer cells interact to produce interleukin‐8 (CINC) in the setting of ethanol publication-title: Am J Physiol Gastrointest Liver Physiol – volume: 136 start-page: 1639 year: 2009 end-page: 1650 article-title: Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis publication-title: Gastroenterology – volume: 3 start-page: 1260 year: 2005 end-page: 1268 article-title: Joint effects of body weight and alcohol on elevated serum alanine aminotransferase in the United States population publication-title: Clin Gastroenterol Hepatol – volume: 54 start-page: 1620 year: 2011 end-page: 1630 article-title: Nuclear factor high‐mobility group box1 mediating the activation of Toll‐like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice publication-title: Hepatology – year: 2015 ident: hep27921-bib-0044-20241017 article-title: TLR2 and TLR9 contribute to alcohol‐mediated liver injury through induction of CXCL1 and neutrophil infiltration publication-title: Am J Physiol Gastrointest Liver Physiol – volume: 18 start-page: 217 year: 2000 ident: hep27921-bib-0022-20241017 article-title: The biology of chemokines and their receptors publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.18.1.217 – volume: 230 start-page: 573 year: 2005 ident: hep27921-bib-0032-20241017 article-title: Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils publication-title: Exp Biol Med (Maywood) doi: 10.1177/153537020523000809 – volume: 287 start-page: 24378 year: 2012 ident: hep27921-bib-0016-20241017 article-title: Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin‐4 publication-title: J Biol Chem doi: 10.1074/jbc.M112.371807 – volume: 17 start-page: 1168 year: 2003 ident: hep27921-bib-0047-20241017 article-title: CINC‐1 is an acute‐phase protein induced by focal brain injury causing leukocyte mobilization and liver injury publication-title: FASEB J doi: 10.1096/fj.02-0757fje – volume: 3 start-page: 1260 year: 2005 ident: hep27921-bib-0005-20241017 article-title: Joint effects of body weight and alcohol on elevated serum alanine aminotransferase in the United States population publication-title: Clin Gastroenterol Hepatol doi: 10.1016/S1542-3565(05)00743-3 – volume: 88 start-page: 1097 year: 2008 ident: hep27921-bib-0006-20241017 article-title: Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index publication-title: Am J Clin Nutr doi: 10.1093/ajcn/88.4.1097 – volume: 139 start-page: 664 year: 2010 ident: hep27921-bib-0040-20241017 article-title: Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol‐induced liver injury in mice publication-title: Gastroenterology doi: 10.1053/j.gastro.2010.04.041 – volume: 25 start-page: 624 year: 1997 ident: hep27921-bib-0049-20241017 article-title: Adenovirus‐mediated expression of cytokine‐induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis publication-title: Hepatology doi: 10.1002/hep.510250322 – volume: 116 start-page: 3015 year: 2006 ident: hep27921-bib-0030-20241017 article-title: TLR4 links innate immunity and fatty acid‐induced insulin resistance publication-title: J Clin Invest doi: 10.1172/JCI28898 – volume: 58 start-page: 1814 year: 2013 ident: hep27921-bib-0039-20241017 article-title: Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E‐selectin publication-title: Hepatology doi: 10.1002/hep.26419 – volume: 269 start-page: G518 year: 1995 ident: hep27921-bib-0028-20241017 article-title: Rat hepatocytes and Kupffer cells interact to produce interleukin‐8 (CINC) in the setting of ethanol publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.1995.269.4.G518 – volume: 22 start-page: 820 year: 2010 ident: hep27921-bib-0007-20241017 article-title: A cohort study of the effect of alcohol consumption and obesity on serum liver enzyme levels publication-title: Eur J Gastroenterol Hepatol doi: 10.1097/MEG.0b013e3283328b86 – volume: 13 start-page: 159 year: 2013 ident: hep27921-bib-0020-20241017 article-title: Neutrophil recruitment and function in health and inflammation publication-title: Nat Rev Immunol doi: 10.1038/nri3399 – volume: 25 start-page: 787 year: 2007 ident: hep27921-bib-0045-20241017 article-title: Chemokine: receptor structure, interactions, and antagonism publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.24.021605.090529 – volume: 6 start-page: 814 year: 1986 ident: hep27921-bib-0012-20241017 article-title: Ethanol‐induced liver fibrosis in rats fed high fat diet publication-title: Hepatology doi: 10.1002/hep.1840060503 – volume: 288 start-page: G880 year: 2005 ident: hep27921-bib-0048-20241017 article-title: Generation and functional significance of CXC chemokines for neutrophil‐induced liver injury during endotoxemia publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00317.2004 – volume: 55 start-page: 673 year: 2011 ident: hep27921-bib-0013-20241017 article-title: Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p‐AMPK publication-title: J Hepatol doi: 10.1016/j.jhep.2010.12.034 – volume: 43 start-page: 1220 year: 2006 ident: hep27921-bib-0037-20241017 article-title: Neutrophil depletion protects against murine acetaminophen hepatotoxicity publication-title: Hepatology doi: 10.1002/hep.21175 – volume: 11 start-page: 224 year: 2014 ident: hep27921-bib-0033-20241017 article-title: The role of neutrophils in the development of liver diseases publication-title: Cell Mol Immunol doi: 10.1038/cmi.2014.2 – volume: 305 start-page: E388 year: 2013 ident: hep27921-bib-0018-20241017 article-title: Adipose tissue inflammation contributes to short‐term high‐fat diet‐induced hepatic insulin resistance publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00179.2013 – volume: 35 start-page: 1361 year: 2011 ident: hep27921-bib-0010-20241017 article-title: A new model of interactive effects of alcohol and high‐fat diet on hepatic fibrosis publication-title: Alcohol Clin Exp Res doi: 10.1111/j.1530-0277.2011.01472.x – volume: 8 start-page: e80848 year: 2013 ident: hep27921-bib-0024-20241017 article-title: Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent publication-title: PLoS One doi: 10.1371/journal.pone.0080848 – volume: 25 start-page: 108 year: 1997 ident: hep27921-bib-0001-20241017 article-title: Excess weight risk factor for alcoholic liver disease publication-title: Hepatology doi: 10.1002/hep.510250120 – volume: 37 start-page: 332 year: 2013 ident: hep27921-bib-0003-20241017 article-title: Body fat distribution and risk factors for fibrosis in patients with alcoholic liver disease publication-title: Alcohol Clin Exp Res doi: 10.1111/j.1530-0277.2012.01927.x – volume: 54 start-page: 1620 year: 2011 ident: hep27921-bib-0042-20241017 article-title: Nuclear factor high‐mobility group box1 mediating the activation of Toll‐like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice publication-title: Hepatology doi: 10.1002/hep.24552 – volume: 304 start-page: G38 year: 2013 ident: hep27921-bib-0015-20241017 article-title: Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00309.2012 – volume: 86 start-page: 183 year: 2010 ident: hep27921-bib-0019-20241017 article-title: Molecular regulators of leucocyte chemotaxis during inflammation publication-title: Cardiovasc Res doi: 10.1093/cvr/cvq040 – volume: 147 start-page: 577 year: 2014 ident: hep27921-bib-0021-20241017 article-title: Roles for chemokines in liver disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.06.043 – volume: 275 start-page: 122 year: 2014 ident: hep27921-bib-0034-20241017 article-title: Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans publication-title: Toxicol Appl Pharmacol doi: 10.1016/j.taap.2014.01.004 – volume: 136 start-page: 1639 year: 2009 ident: hep27921-bib-0023-20241017 article-title: Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.01.056 – volume: 162 start-page: 3031 year: 1999 ident: hep27921-bib-0041-20241017 article-title: Ethanol‐induced macrophage apoptosis: the role of TGF‐beta publication-title: J Immunol doi: 10.4049/jimmunol.162.5.3031 – volume: 275 start-page: G847 year: 1998 ident: hep27921-bib-0027-20241017 article-title: Rat hepatic stellate cells produce cytokine‐induced neutrophil chemoattractant in culture and in vivo publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.1998.275.4.G847 – volume: 30 start-page: 1137 year: 2009 ident: hep27921-bib-0008-20241017 article-title: Synergistic association between alcohol intake and body mass index with serum alanine and aspartate aminotransferase levels in older adults: the Rancho Bernardo Study publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2009.04141.x – volume: 47 start-page: 235 year: 1988 ident: hep27921-bib-0002-20241017 article-title: Overweight as a risk factor or a predictive sign of histological liver damage in alcoholics publication-title: Am J Clin Nutr doi: 10.1093/ajcn/47.2.235 – volume: 44 start-page: 107 year: 2012 ident: hep27921-bib-0036-20241017 article-title: Role of immune reactions in drug‐induced liver injury (DILI) publication-title: Drug Metab Rev doi: 10.3109/03602532.2011.645579 – volume: 5 start-page: e13577 year: 2010 ident: hep27921-bib-0050-20241017 article-title: Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients publication-title: PLoS One doi: 10.1371/journal.pone.0013577 – volume: 75 start-page: 443 year: 2004 ident: hep27921-bib-0026-20241017 article-title: Critical role of CXC chemokines in endotoxemic liver injury in mice publication-title: J Leukoc Biol doi: 10.1189/jlb.0603297 – volume: 46 start-page: 823 year: 2007 ident: hep27921-bib-0029-20241017 article-title: Palmitic acid induces production of proinflammatory cytokine interleukin‐8 from hepatocytes publication-title: Hepatology doi: 10.1002/hep.21752 – volume: 29 start-page: 1944 year: 2009 ident: hep27921-bib-0031-20241017 article-title: Saturated fatty acids do not directly stimulate Toll‐like receptor signaling publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.109.194050 – volume: 27 start-page: 23 year: 2002 ident: hep27921-bib-0038-20241017 article-title: Neutrophil‐mediated tissue injury in alcoholic hepatitis publication-title: Alcohol doi: 10.1016/S0741-8329(02)00200-8 – volume: 27 start-page: 1172 year: 1998 ident: hep27921-bib-0046-20241017 article-title: Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein‐2 and KC publication-title: Hepatology doi: 10.1002/hep.510270441 – volume: 42 start-page: 1280 year: 2005 ident: hep27921-bib-0014-20241017 article-title: Alcohol increases tumor necrosis factor alpha and decreases nuclear factor‐kappaB to activate hepatic apoptosis in genetically obese mice publication-title: Hepatology doi: 10.1002/hep.20949 – volume: 56 start-page: 1971 year: 2012 ident: hep27921-bib-0035-20241017 article-title: Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure publication-title: Hepatology doi: 10.1002/hep.25801 – volume: 60 start-page: 2474 year: 2011 ident: hep27921-bib-0017-20241017 article-title: Inflammation is necessary for long‐term but not short‐term high‐fat diet‐induced insulin resistance publication-title: Diabetes doi: 10.2337/db11-0194 – volume: 10 start-page: 2423 year: 2004 ident: hep27921-bib-0004-20241017 article-title: Risk factors for alcoholic liver disease in China publication-title: World J Gastroenterol doi: 10.3748/wjg.v10.i16.2423 – volume: 61 start-page: 1058 year: 2012 ident: hep27921-bib-0043-20241017 article-title: Toll‐like receptor‐4 mediates obesity‐induced non‐alcoholic steatohepatitis through activation of X‐box binding protein‐1 in mice publication-title: Gut doi: 10.1136/gutjnl-2011-300269 – volume: 14 start-page: 117 year: 2008 ident: hep27921-bib-0025-20241017 article-title: Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO‐alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)‐induced colitis publication-title: Innate Immun doi: 10.1177/1753425908088724 – volume: 40 start-page: 185 year: 2006 ident: hep27921-bib-0011-20241017 article-title: Combined effects of high‐fat diet and ethanol induce oxidative stress in rat liver publication-title: Alcohol doi: 10.1016/j.alcohol.2006.12.006 – volume: 340 start-page: c1240 year: 2010 ident: hep27921-bib-0009-20241017 article-title: Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies publication-title: BMJ doi: 10.1136/bmj.c1240 |
| SSID | ssj0009428 |
| Score | 2.5634165 |
| Snippet | Obesity and alcohol consumption often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. Here, we... |
| SourceID | pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1070 |
| SubjectTerms | Acute Disease Animals Binge Drinking - complications Chemokine CXCL1 - physiology Diet, High-Fat - adverse effects Ethanol - administration & dosage Fatty acids Fatty Liver - etiology Hepatology Kinases Liver Diseases - etiology Liver Diseases - immunology Male Mice Mice, Inbred C57BL Neutrophil Infiltration Rodents Time Factors |
| Title | Short‐ or long‐term high‐fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1 |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhep.27921 https://www.ncbi.nlm.nih.gov/pubmed/26033752 https://www.proquest.com/docview/1717286177 https://www.proquest.com/docview/1718330711 https://www.proquest.com/docview/1722177221 https://pubmed.ncbi.nlm.nih.gov/PMC4589443 |
| Volume | 62 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELaqHhAXKP-hBRnEgUu2SezECZyqVasVoggBlfaAFNmOzS6kyaqbHMqJR-DG-_EkzDg_ZSkghCIlVjKREmdm_I09-YaQJ3GSKR0FhS-LIPB5FGR-qgz3meWRTHiimSsHdPwqmZ3wF_N4vkWeD__CdPwQ44QbWobz12jgUq33L0hDF2Y1QfY7DH0wVwsB0ZsL6qiMu7qqEHUFuLqcDaxCQbQ_3rk5Fl0CmJfzJH_Gr24AOrpO3g-P3uWdfJq0jZroz7-wOv7nu-2Qaz0wpQedJt0gW6a6Sa4c90vvt8i3twtA6t-_fKX1GS3r6gM00a1TJDyGtpUNLZamobYbD-mqbNdU6rYx1OD8fF1ShXOIdH2O_xs6gmhZlud0WRWgX71oiXkicOojfGs40FNwZM_oQUWXpy5SqBqKCZEUsDadzqcvw9vk5Ojw3XTm91UdfB0LEfrCGislBMZZzBVsJgxZWkhb8EJqkyTgRTQGgoG2vEh5VsRMS5OaSDMjdMzZHbJd1ZW5R6jlmbAAUaXFCF8EMmaZsiZRIZxQaeCRp8P3zXVPeY6VN8q8I2uOcujo3HW0Rx6PoquO5-N3QnuDkuS9qa_zUGCJLwCCwiOPxstgpLjyIitTt04mZeBNw_BvMhGEh7jzyN1O78YngaCTMRFHHhEbGjkKIEn45pVquXBk4TxOM84ZdIVTuD-_XD47fO0a9_9ddJdcBQAZd8mNe2S7OWvNAwBpjXrorPEHC9w9lA |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELaqIgEX_imBAgZx4JJtEtv5QVyqpdUCuxWCVtoLihzHZhfSZNVNDuXEI3Dj_XgSZpxsylJACEVKrGQiJc7M-Bt78g0hT0SYZCrwclfmnufywEvcONPcZYYHMuShYrYc0OQgHB3xV1Mx3SDPV__CtPwQ_YQbWob112jgOCG9c8YaOtOLAdLfQexzASt6I3P-i7dn5FEJt5VVIe7ycH05WfEKecFOf-v6aHQOYp7PlPwZwdohaP8qeb96-Dbz5NOgqbOB-vwLr-P_vt01cqXDpnS3VabrZEOXN8jFSbf6fpN8ezcDsP79y1dandCiKj9AEz07Rc5jaBtZ03yua2raIZEuimZJpWpqTTVO0VcFzXAakS5P8ZdDyxEti-KUzsscVKwTLTBVBE59hM8NB3oMvuwZ3S3p_NgGC2VNMSeSAtymw-lw7N8iR_t7h8OR2xV2cJWIIt-NjDZSQmycCJ7Bpn2fxbk0Oc-l0mEIjkRhLOgpw_OYJ7lgSupYB4rpSAnObpPNsir1HUINTyIDKFUaDPIjTwqWZEaHmQ8nsthzyNPVB05Vx3qOxTeKtOVrDlLo6NR2tEMe96KLlurjd0LbKy1JO2tfpn6EVb4AC0YOedRfBjvFxRdZ6qqxMjEDh-r7f5MJIELEnUO2WsXrnwTiTsYiETgkWlPJXgB5wtevlPOZ5QvnIk44Z9AVVuP-_HLpaO-Nbdz9d9GH5NLocDJOxy8PXt8jlwFPijbXcZts1ieNvg-Yrc4eWNP8AatxQbA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELaqIlVc-P9JKWAQBy7ZOrEdJ3Cqtl0t0FYVUGkPSJHj2OzSNFl1k0M58QjceD-ehLGTTVkKCKFIiZVMpMSZGX9jT75B6BmPkkyFJPdlTojPQpL4caaZTw0LZcQiRV05oIPDaHzMXk_4ZA29XP4L0_JD9BNu1jKcv7YGPs_N9gVp6FTPB5b9DkKfKywiia3bsPv2gjsqYa6wKoRdxC4vJ0taIRJu97euDkaXEOblRMmfAawbgUbX0Yfls7eJJyeDps4G6vMvtI7_-XI30LUOmeKdVpVuojVd3kIbB93a-2307d0UoPr3L19xdYaLqvwITevXsWU8hraRNc5nusamHRDxvGgWWKqm1ljbCfqqwJmdRMSLc_vDoWOIlkVxjmdlDgrWiRY2UQROfYKPDQd8Cp7sBd4p8ezUhQpljW1GJAawjYeT4X5wBx2P9t4Px35X1sFXXIjAF0YbKSEyTjjLYNNBQONcmpzlUukoAjeibCRIlGF5zJKcUyV1rENFtVCc0btovaxKfR9hwxJhAKNKY0N8QSSnSWZ0lAVwIouJh54vv2-qOs5zW3qjSFu25jCFjk5dR3voaS86b4k-fie0tVSStLP1RRoIW-MLkKDw0JP-MlipXXqRpa4aJxNTcKdB8DeZEOJDu_PQvVbv-ieBqJNSwUMPiRWN7AUsS_jqlXI2dWzhjMcJYxS6wincn18uHe8ducbmv4s-RhtHu6N0_9XhmwfoKoBJ3iY6bqH1-qzRDwGw1dkjZ5g_AMZXQF8 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Short%E2%80%90+or+long%E2%80%90term+high%E2%80%90fat+diet+feeding+plus+acute+ethanol+binge+synergistically+induce+acute+liver+injury+in+mice%3A+An+important+role+for+CXCL1&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.au=Chang%2C+Binxia&rft.au=Xu%2C+Ming%E2%80%90Jiang&rft.au=Zhou%2C+Zhou&rft.au=Cai%2C+Yan&rft.date=2015-10-01&rft.issn=0270-9139&rft.eissn=1527-3350&rft.volume=62&rft.issue=4&rft.spage=1070&rft.epage=1085&rft_id=info:doi/10.1002%2Fhep.27921&rft.externalDBID=10.1002%252Fhep.27921&rft.externalDocID=HEP27921 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-9139&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-9139&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-9139&client=summon |