ALT/AST as an Independent Risk Factor of Gestational Diabetes Mellitus Compared with TG/HDL-C

• Published in: International journal of general medicine Vol. 15; pp. 115 - 121
• Main Authors: Song, Shuoning, Zhang, Yuemei, Qiao, Xiaolin, Duo, Yanbei, Xu, Jiyu, Peng, Zhenyao, Zhang, Jing, Chen, Yan, Nie, Xiaorui, Sun, Qiujin, Yang, Xianchun, Wang, Ailing, Lu, Zechun, Sun, Wei, Fu, Yong, Dong, Yingyue, Yuan, Tao, Zhao, Weigang
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2022; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Adjustment; Age; alanine transaminase; aspartate aminotransferase; Blood pressure; Blood sugar; Body mass index; Childrens health; Cholesterol; Chronic illnesses; Comparative analysis; Diabetes in pregnancy; Family medical history; Gestational diabetes; gestational diabetes mellitus; Glucose; Glucose tolerance tests; High density lipoprotein; Insulin resistance; Laboratories; Lipids; Lipoproteins; Liver diseases; Maternal & child health; Metabolism; Original Research; Pregnancy complications; Pregnant women; Regression analysis; Risk factors; triglyceride; Type 2 diabetes; type 2 diabetes mellitus; Womens health; China; Taiwan; triglyceride; type 2 diabetes mellitus; gestational diabetes mellitus; alanine transaminase; aspartate aminotransferase
• DOI: 10.2147/IJGM.S332946
• ISSN: 1178-7074

This study aimed to find the association between alanine transaminase-to-aspartate aminotransferase ratio (ALT/AST) and the incidence of gestational diabetes mellitus (GDM). A total of 1128 pregnant women were included in this prospective, double-center, observational cohort study. ALT, AST and total bilirubin (TBil) were tested during 6-12 weeks of gestation and 75-g oral glucose tolerance test (OGTT) was conducted during 24-28 weeks of gestation to screen GDM. The association between ALT/AST and glucose concentration during OGTT was analyzed by linear regression model. The OR with 95% CI for incidence of GDM associated with ALT/AST was estimated by binary logistic regression. The discriminatory values of ALT/AST and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) for GDM were calculated by the area under the receiver operating characteristic curve (ROC-AUC). The incidence of GDM was 22.07% (249/1128). ALT/AST was higher in GDM group than in NGT group (0.92 [0.75, 1.18] vs 0.80[0.65, 1.02], <0.001). ALT/AST had positive correlations with fasting blood glucose, 1-hour and 2-hour blood glucose concentration during OGTT (0.089 [95% CI: 0.034, 0.163], 0.176 [95% CI: 0.052, 0.104], and 0.115 [95% CI: 0.199, 0.609], respectively). The OR of ALT/AST for incidence of GDM was 1.603 (95% CI:1.097, 2.344). The ROC-AUC of ALT/AST and TG/HDL-C reached 0.615 (95% CI: 0.575, 0.655) and 0.619 (95% CI: 0.580, 0.659), respectively. ALT/AST in early pregnancy was an independent risk factor of GDM. The predictive ability of ALT/AST was similar to TG/HDL-C for GDM.