Chronic Rhinosinusitis with Nasal Polyps: Targeting IgE with Anti-IgE Omalizumab Therapy

• Published in: Drug design, development and therapy Vol. 14; pp. 5483 - 5494
• Main Authors: Kariyawasam, Harsha H, James, Louisa K
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Allergens; Allergies; Antibodies; Antigens; Asthma; B cells; Binding sites; Biomarkers; Cytokines; ige; Immunoglobulin E; Immunoglobulins; Immunology; Immunotherapy; Inflammation; Inflammatory diseases; Medical research; Medicine, Experimental; Monoclonal antibodies; Nasal polyps; Omalizumab; Pathogenesis; Polyps; Review; Rhinitis; Rhinosinusitis; Sinusitis; United Kingdom; nasal polyps; omalizumab; rhinosinusitis; IgE

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex, clinically heterogeneous and persistent inflammatory disorder of the upper airway. Detailed mechanistic insights into disease pathogenesis are lacking, but it is now accepted that local tissue IgE driven T2-high inflammatory pathways ar...