Investigation of genes important in neurodevelopment disorders in adult human brain

• Published in: Human genetics Vol. 134; no. 10; pp. 1037 - 1053
• Main Authors: Maussion, Gilles, Diallo, Alpha B., Gigek, Carolina O., Chen, Elizabeth S., Crapper, Liam, Théroux, Jean-Francois, Chen, Gary G., Vasuta, Cristina, Ernst, Carl
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2015; Springer; Springer Nature B.V
• Subjects: Adult; Analysis; Autism; Base Sequence; Biomedical and Life Sciences; Biomedicine; Brain; Cell Line; Consensus Sequence; Disease; Frontal Lobe - metabolism; Frontal Lobe - pathology; Gene Expression; Gene Expression Regulation; Gene Function; Gene Ontology; Genes; Genomes; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Human Genetics; Humans; Hypotheses; Intellectual disabilities; Investigations; Matrix Attachment Region Binding Proteins - genetics; Matrix Attachment Region Binding Proteins - metabolism; Metabolic Diseases; Middle Aged; Molecular Medicine; Mutation; Neural Stem Cells - physiology; Neurodevelopmental Disorders - genetics; Neurodevelopmental Disorders - metabolism; Neurodevelopmental Disorders - pathology; Original Investigation; Stem cells; Transcription Factor 7-Like 2 Protein - genetics; Transcription Factor 7-Like 2 Protein - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Young Adult; Canada; Montreal Quebec Canada; Autism Spectrum Disorder; Neural Stem Cell; Adult Brain; Fetal Brain; Adult Human Brain

Several neurodevelopmental disorders (NDDs) are caused by mutations in genes expressed in fetal brain, but little is known about these same genes in adult human brain. Here, we test the hypothesis that genes associated with NDDs continue to have a role in adult human brain to explore the idea that N...