Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task

We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlati...

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Published ineLife Vol. 10
Main Authors Yang, Hongdian, Bari, Bilal A, Cohen, Jeremiah Y, O'Connor, Daniel H
Format Journal Article
LanguageEnglish
Published England eLife Science Publications, Ltd 15.03.2021
eLife Sciences Publications Ltd
eLife Sciences Publications, Ltd
Subjects
Analysis
Behavior
Cortex (somatosensory)
Depolarization
False alarms
Hypotheses
Locus coeruleus
Membrane potential
Neuroscience
norepinephrine
Physiological aspects
Probability
pupil
Short Report
somatosensory cortex
Stimuli (Psychology)
tactile
Tactile stimuli
United States
norepinephrine
mouse
neuroscience
tactile
somatosensory cortex
locus coeruleus
S1
pupil
Online AccessGet full text
ISSN2050-084X
2050-084X
DOI10.7554/eLife.64327

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Abstract We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.
AbstractList We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.
We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.
Audience Academic
Author O'Connor, Daniel H
Yang, Hongdian
Bari, Bilal A
Cohen, Jeremiah Y
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33721552$$D View this record in MEDLINE/PubMed
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Keywords norepinephrine
mouse
neuroscience
tactile
somatosensory cortex
locus coeruleus
S1
pupil
Language English
License 2021, Yang et al.
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Snippet We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice...
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SubjectTerms Analysis
Behavior
Cortex (somatosensory)
Depolarization
False alarms
Hypotheses
Locus coeruleus
Membrane potential
Neuroscience
norepinephrine
Physiological aspects
Probability
pupil
Short Report
somatosensory cortex
Stimuli (Psychology)
tactile
Tactile stimuli
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Title Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task
URI https://www.ncbi.nlm.nih.gov/pubmed/33721552
https://www.proquest.com/docview/2595183070
https://www.proquest.com/docview/2501848710
https://pubmed.ncbi.nlm.nih.gov/PMC7963470
https://doaj.org/article/f032669c3f2f4afeb8f255cb412d5cdf
Volume 10
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