Snake venom toxins: toxicity and medicinal applications

Snake venoms are complex mixtures of small molecules and peptides/proteins, and most of them display certain kinds of bioactivities. They include neurotoxic, cytotoxic, cardiotoxic, myotoxic, and many different enzymatic activities. Snake envenomation is a significant health issue as millions of sna...

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Published inApplied microbiology and biotechnology Vol. 100; no. 14; pp. 6165 - 6181
Main Authors Chan, Yau Sang, Cheung, Randy Chi Fai, Xia, Lixin, Wong, Jack Ho, Ng, Tzi Bun, Chan, Wai Yee
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2016
Springer
Springer Nature B.V
Subjects
Alzheimer's disease
analgesic effect
Analgesics
Analgesics - analysis
Analgesics - pharmacology
Analysis
Animals
Anti-Infective Agents - analysis
Anti-Infective Agents - pharmacology
Anticoagulants - analysis
Anticoagulants - pharmacology
Antineoplastic Agents - analysis
Antineoplastic Agents - pharmacology
Biomedical and Life Sciences
Biotechnology
Cancer
Cardiac function
Clinical Trials as Topic
Cytotoxicity
Enzymatic activity
enzyme activity
Enzymes
Health aspects
Humans
Life Sciences
Lipids
Medical research
Medicine
Microbial Genetics and Genomics
Microbiology
Mini-Review
Neurotoxicity
people
Peptides
Peptides - analysis
poisoning
Poisons
Protein Conformation
Proteins
Proteins - analysis
Reptiles & amphibians
Snake bites
Snake venoms
Snake Venoms - chemistry
Snake Venoms - pharmacology
Snakes
Studies
Therapy
Toxicity
Toxins
Venom
venoms
Toxin
Therapeutic
Snake
Venom
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Abstract Snake venoms are complex mixtures of small molecules and peptides/proteins, and most of them display certain kinds of bioactivities. They include neurotoxic, cytotoxic, cardiotoxic, myotoxic, and many different enzymatic activities. Snake envenomation is a significant health issue as millions of snakebites are reported annually. A large number of people are injured and die due to snake venom poisoning. However, several fatal snake venom toxins have found potential uses as diagnostic tools, therapeutic agent, or drug leads. In this review, different non-enzymatically active snake venom toxins which have potential therapeutic properties such as antitumor, antimicrobial, anticoagulating, and analgesic activities will be discussed.
AbstractList Snake venoms are complex mixtures of small molecules and peptides/proteins, and most of them display certain kinds of bioactivities. They include neurotoxic, cytotoxic, cardiotoxic, myotoxic, and many different enzymatic activities. Snake envenomation is a significant health issue as millions of snakebites are reported annually. A large number of people are injured and die due to snake venom poisoning. However, several fatal snake venom toxins have found potential uses as diagnostic tools, therapeutic agent, or drug leads. In this review, different non-enzymatically active snake venom toxins which have potential therapeutic properties such as antitumor, antimicrobial, anticoagulating, and analgesic activities will be discussed.
Audience Academic
Author Cheung, Randy Chi Fai
Chan, Wai Yee
Ng, Tzi Bun
Xia, Lixin
Wong, Jack Ho
Chan, Yau Sang
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  fullname: Chan, Wai Yee
  email: chanwy@cuhk.edu.hk
  organization: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27245678$$D View this record in MEDLINE/PubMed
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ISSN 0175-7598
IngestDate Fri Jul 11 03:15:54 EDT 2025
Tue Aug 05 09:30:25 EDT 2025
Wed Aug 13 10:59:29 EDT 2025
Tue Jun 17 21:17:47 EDT 2025
Tue Jun 10 20:39:04 EDT 2025
Fri Jun 27 04:58:44 EDT 2025
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Tue Jul 01 03:48:18 EDT 2025
Thu Apr 24 23:13:24 EDT 2025
Fri Feb 21 02:37:34 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 14
Keywords Toxin
Therapeutic
Snake
Venom
Language English
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SubjectTerms Alzheimer's disease
analgesic effect
Analgesics
Analgesics - analysis
Analgesics - pharmacology
Analysis
Animals
Anti-Infective Agents - analysis
Anti-Infective Agents - pharmacology
Anticoagulants - analysis
Anticoagulants - pharmacology
Antineoplastic Agents - analysis
Antineoplastic Agents - pharmacology
Biomedical and Life Sciences
Biotechnology
Cancer
Cardiac function
Clinical Trials as Topic
Cytotoxicity
Enzymatic activity
enzyme activity
Enzymes
Health aspects
Humans
Life Sciences
Lipids
Medical research
Medicine
Microbial Genetics and Genomics
Microbiology
Mini-Review
Neurotoxicity
people
Peptides
Peptides - analysis
poisoning
Poisons
Protein Conformation
Proteins
Proteins - analysis
Reptiles & amphibians
Snake bites
Snake venoms
Snake Venoms - chemistry
Snake Venoms - pharmacology
Snakes
Studies
Therapy
Toxicity
Toxins
Venom
venoms
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Title Snake venom toxins: toxicity and medicinal applications
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