Mechanisms and Consequences of Variable TRPA1 Expression by Airway Epithelial Cells: Effects of TRPV1 Genotype and Environmental Agonists on Cellular Responses to Pollutants in Vitro and Asthma

• Published in: Environmental health perspectives Vol. 131; no. 2; p. 27009
• Main Authors: Rapp, Emmanuel, Lu, Zhenyu, Sun, Lili, Serna, Samantha N, Almestica-Roberts, Marysol, Burrell, Katherine L, Nguyen, Nam D, Deering-Rice, Cassandra E, Reilly, Christopher A
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences 01.02.2023; Environmental Health Perspectives
• Subjects: Air Pollutants - toxicity; Air pollution; Air quality management; Airway (Medicine); Analysis; Asthma; Asthma in children; B cells; Child; Development and progression; Dust; Environmental aspects; Environmental Pollutants; Epithelial Cells; Genetic aspects; Health aspects; Humans; Ion channels; Physiological aspects; Pollutants; Protein kinases; RNA; Smoking; Tobacco Smoke Pollution; TRPA1 Cation Channel - genetics; TRPV Cation Channels - genetics; South Korea; Canada; Utah

Transient receptor potential ankyrin-1 [transient receptor potential cation channel subfamily A member 1 (TRPA1)] and vanilloid-1 [transient receptor potential cation channel subfamily V member 1 (TRPV1)] detect inhaled irritants, including air pollutants and have roles in the development and exacer...