PTEN regulates RPA1 and protects DNA replication forks

• Published in: Cell research Vol. 25; no. 11; pp. 1189 - 1204
• Main Authors: Wang, Guangxi, Li, Yang, Wang, Pan, Liang, Hui, Cui, Ming, Zhu, Minglu, Guo, Limei, Su, Qian, Sun, Yujie, McNutt, Michael A, Yin, Yuxin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2015; Nature Publishing Group
• Subjects: 631/80/641/151; 631/80/86; Animals; Biomedical and Life Sciences; C-末端; Cell Biology; Chromosomal Instability; Colorectal carcinoma; Deoxyribonucleic acid; DNA; DNA Replication; DNA复制; Genomic Instability; Life Sciences; Original; original-article; PTEN基因; Replication Protein A - genetics; 压力保护; 染色体不稳定性; 物理相关; 肿瘤抑制基因; 调控; replication; PTEN; RPA1; fork protection; OTUB1

Tumor suppressor PTEN regulates cellular activities and controls genome stability through multiple mechanisms. In this study, we report that PTEN is necessary for the protection of DNA replication forks against replication stress. We show that deletion of PTEN leads to replication fork collapse and...