The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation

• Published in: Cancer discovery Vol. 9; no. 12; pp. 1708 - 1719
• Main Authors: Wang, Lin, Babikir, Husam, Müller, Sören, Yagnik, Garima, Shamardani, Karin, Catalan, Francisca, Kohanbash, Gary, Alvarado, Beatriz, Di Lullo, Elizabeth, Kriegstein, Arnold, Shah, Sumedh, Wadhwa, Harsh, Chang, Susan M, Phillips, Joanna J, Aghi, Manish K, Diaz, Aaron A
• Format: Journal Article
• Language: English
• Published: United States 01.12.2019

Although tumor-propagating cells can be derived from glioblastomas (GBM) of the proneural and mesenchymal subtypes, a glioma stem-like cell (GSC) of the classic subtype has not been identified. It is unclear whether mesenchymal GSCs (mGSC) and/or proneural GSCs (pGSC) alone are sufficient to generat...