Brain activities associated with gaming urge of online gaming addiction
The aim of this study was to identify the neural substrates of online gaming addiction through evaluation of the brain areas associated with the cue-induced gaming urge. Ten participants with online gaming addiction and 10 control subjects without online gaming addiction were tested. They were prese...
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Published in | Journal of psychiatric research Vol. 43; no. 7; pp. 739 - 747 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Kidlington
Elsevier Ltd
01.04.2009
Elsevier |
Subjects | |
Online Access | Get full text |
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Abstract | The aim of this study was to identify the neural substrates of online gaming addiction through evaluation of the brain areas associated with the cue-induced gaming urge. Ten participants with online gaming addiction and 10 control subjects without online gaming addiction were tested. They were presented with gaming pictures and the paired mosaic pictures while undergoing functional magnetic resonance imaging (fMRI) scanning. The contrast in blood-oxygen-level dependent (BOLD) signals when viewing gaming pictures and when viewing mosaic pictures was calculated with the SPM2 software to evaluate the brain activations. Right orbitofrontal cortex, right nucleus accumbens, bilateral anterior cingulate and medial frontal cortex, right dorsolateral prefrontal cortex, and right caudate nucleus were activated in the addicted group in contrast to the control group. The activation of the region-of-interest (ROI) defined by the above brain areas was positively correlated with self-reported gaming urge and recalling of gaming experience provoked by the WOW pictures. The results demonstrate that the neural substrate of cue-induced gaming urge/craving in online gaming addiction is similar to that of the cue-induced craving in substance dependence. The above-mentioned brain regions have been reported to contribute to the craving in substance dependence, and here we show that the same areas were involved in online gaming urge/craving. Thus, the results suggest that the gaming urge/craving in online gaming addiction and craving in substance dependence might share the same neurobiological mechanism. |
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AbstractList | Abstract The aim of this study was to identify the neural substrates of online gaming addiction through evaluation of the brain areas associated with the cue-induced gaming urge. Ten participants with online gaming addiction and 10 control subjects without online gaming addiction were tested. They were presented with gaming pictures and the paired mosaic pictures while undergoing functional magnetic resonance imaging (fMRI) scanning. The contrast in blood-oxygen-level dependent (BOLD) signals when viewing gaming pictures and when viewing mosaic pictures was calculated with the SPM2 software to evaluate the brain activations. Right orbitofrontal cortex, right nucleus accumbens, bilateral anterior cingulate and medial frontal cortex, right dorsolateral prefrontal cortex, and right caudate nucleus were activated in the addicted group in contrast to the control group. The activation of the region-of-interest (ROI) defined by the above brain areas was positively correlated with self-reported gaming urge and recalling of gaming experience provoked by the WOW pictures. The results demonstrate that the neural substrate of cue-induced gaming urge/craving in online gaming addiction is similar to that of the cue-induced craving in substance dependence. The above-mentioned brain regions have been reported to contribute to the craving in substance dependence, and here we show that the same areas were involved in online gaming urge/craving. Thus, the results suggest that the gaming urge/craving in online gaming addiction and craving in substance dependence might share the same neurobiological mechanism. The aim of this study was to identify the neural substrates of online gaming addiction through evaluation of the brain areas associated with the cue-induced gaming urge. Ten participants with online gaming addiction and 10 control subjects without online gaming addiction were tested. They were presented with gaming pictures and the paired mosaic pictures while undergoing functional magnetic resonance imaging (fMRI) scanning. The contrast in blood-oxygen-level dependent (BOLD) signals when viewing gaming pictures and when viewing mosaic pictures was calculated with the SPM2 software to evaluate the brain activations. Right orbitofrontal cortex, right nucleus accumbens, bilateral anterior cingulate and medial frontal cortex, right dorsolateral prefrontal cortex, and right caudate nucleus were activated in the addicted group in contrast to the control group. The activation of the region-of-interest (ROI) defined by the above brain areas was positively correlated with self-reported gaming urge and recalling of gaming experience provoked by the WOW pictures. The results demonstrate that the neural substrate of cue-induced gaming urge/craving in online gaming addiction is similar to that of the cue-induced craving in substance dependence. The above-mentioned brain regions have been reported to contribute to the craving in substance dependence, and here we show that the same areas were involved in online gaming urge/craving. Thus, the results suggest that the gaming urge/craving in online gaming addiction and craving in substance dependence might share the same neurobiological mechanism. The aim of this study was to identify the neural substrates of online gaming addiction through evaluation of the brain areas associated with the cue-induced gaming urge. Ten participants with online gaming addiction and 10 control subjects without online gaming addiction were tested. They were presented with gaming pictures and the paired mosaic pictures while undergoing functional magnetic resonance imaging (fMRI) scanning. The contrast in blood-oxygen-level dependent (BOLD) signals when viewing gaming pictures and when viewing mosaic pictures was calculated with the SPM2 software to evaluate the brain activations. Right orbitofrontal cortex, right nucleus accumbens, bilateral anterior cingulate and medial frontal cortex, right dorsolateral prefrontal cortex, and right caudate nucleus were activated in the addicted group in contrast to the control group. The activation of the region-of-interest (ROI) defined by the above brain areas was positively correlated with self-reported gaming urge and recalling of gaming experience provoked by the WOW pictures. The results demonstrate that the neural substrate of cue-induced gaming urge/craving in online gaming addiction is similar to that of the cue-induced craving in substance dependence. The above-mentioned brain regions have been reported to contribute to the craving in substance dependence, and here we show that the same areas were involved in online gaming urge/craving. Thus, the results suggest that the gaming urge/craving in online gaming addiction and craving in substance dependence might share the same neurobiological mechanism. [Copyright Elsevier Ltd.] |
Author | Lin, Wei-Chen Yen, Cheng-Fang Yang, Ming-Jen Yen, Ju-Yu Ko, Chih-Hung Liu, Gin-Chung Hsiao, Sigmund Chen, Cheng-Sheng |
Author_xml | – sequence: 1 givenname: Chih-Hung surname: Ko fullname: Ko, Chih-Hung organization: Department of Psychiatry, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan – sequence: 2 givenname: Gin-Chung surname: Liu fullname: Liu, Gin-Chung organization: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan – sequence: 3 givenname: Sigmund surname: Hsiao fullname: Hsiao, Sigmund organization: Graduate Institute of Behavioral Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan – sequence: 4 givenname: Ju-Yu surname: Yen fullname: Yen, Ju-Yu organization: Department of Psychiatry, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan – sequence: 5 givenname: Ming-Jen surname: Yang fullname: Yang, Ming-Jen organization: Yuh-Ing Junior College of Health Care and Management, No.15 Lane 420 Dachang 2nd Road, Sanmin District, Kaohsiung 807, Taiwan – sequence: 6 givenname: Wei-Chen surname: Lin fullname: Lin, Wei-Chen email: cyberko@cc.kmuh.org.tw organization: Department of Medical Imaging, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan – sequence: 7 givenname: Cheng-Fang surname: Yen fullname: Yen, Cheng-Fang organization: Department of Psychiatry, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan – sequence: 8 givenname: Cheng-Sheng surname: Chen fullname: Chen, Cheng-Sheng organization: Department of Psychiatry, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan |
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Snippet | The aim of this study was to identify the neural substrates of online gaming addiction through evaluation of the brain areas associated with the cue-induced... Abstract The aim of this study was to identify the neural substrates of online gaming addiction through evaluation of the brain areas associated with the... |
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SubjectTerms | Addiction Adult Behavior, Addictive - diagnosis Behavior, Addictive - physiopathology Behavior, Addictive - psychology Biological and medical sciences Brain - pathology Brain - physiopathology Case-Control Studies Caudate nucleus Caudate Nucleus - physiopathology Cerebral Cortex - physiopathology Cortex Craving Cues fMRI Frontal Lobe - physiopathology Functional Laterality Functional magnetic resonance imaging Gambling - psychology Gaming urge Gyrus Cinguli - physiopathology Humans Image Processing, Computer-Assisted Internet Internet - utilization Internet addiction Magnetic Resonance Imaging Medical sciences Motivation Nucleus accumbens Nucleus Accumbens - physiopathology Photic Stimulation Prefrontal Cortex - physiopathology Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Videogames Visual Perception Young Adult |
Title | Brain activities associated with gaming urge of online gaming addiction |
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