IL-6: Relevance for immunopathology of SARS-CoV-2
•COVID-19 severe outcomes is associated with the respiratory failure and cytokine release syndrome with elevated IL-6 as a predicting parameter.•Chronic inflammation, associated with elevated inflammatory serum cytokines, including IL-6, may exacerbate SARS-CoV-2 induced pathology.•IL-6 is a promisi...
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| Published in | Cytokine & growth factor reviews Vol. 53; pp. 13 - 24 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.06.2020
The Authors. Published by Elsevier Ltd |
| Subjects | |
| Online Access | Get full text |
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| Abstract | •COVID-19 severe outcomes is associated with the respiratory failure and cytokine release syndrome with elevated IL-6 as a predicting parameter.•Chronic inflammation, associated with elevated inflammatory serum cytokines, including IL-6, may exacerbate SARS-CoV-2 induced pathology.•IL-6 is a promising therapeutic target for the anti-cytokine therapy of SARS-CoV-2 severe cases.
COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics. |
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| AbstractList | •
COVID-19 severe outcomes is associated with the respiratory failure and cytokine release syndrome with elevated IL-6 as a predicting parameter.
•
Chronic inflammation, associated with elevated inflammatory serum cytokines, including IL-6, may exacerbate SARS-CoV-2 induced pathology.
•
IL-6 is a promising therapeutic target for the anti-cytokine therapy of SARS-CoV-2 severe cases.
COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics. •COVID-19 severe outcomes is associated with the respiratory failure and cytokine release syndrome with elevated IL-6 as a predicting parameter.•Chronic inflammation, associated with elevated inflammatory serum cytokines, including IL-6, may exacerbate SARS-CoV-2 induced pathology.•IL-6 is a promising therapeutic target for the anti-cytokine therapy of SARS-CoV-2 severe cases. COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics. Highlights•COVID-19 severe outcomes is associated with the respiratory failure and cytokine release syndrome with elevated IL-6 as a predicting parameter. •Chronic inflammation, associated with elevated inflammatory serum cytokines, including IL-6, may exacerbate SARS-CoV-2 induced pathology. •IL-6 is a promising therapeutic target for the anti-cytokine therapy of SARS-CoV-2 severe cases. COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics. |
| Author | Polinova, A.I. Gorshkova, E.A. Gubernatorova, E.O. Drutskaya, M.S. |
| Author_xml | – sequence: 1 givenname: E.O. surname: Gubernatorova fullname: Gubernatorova, E.O. email: ekaterina.gubernatorova412@gmail.com organization: Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia – sequence: 2 givenname: E.A. surname: Gorshkova fullname: Gorshkova, E.A. organization: Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia – sequence: 3 givenname: A.I. surname: Polinova fullname: Polinova, A.I. organization: Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia – sequence: 4 givenname: M.S. surname: Drutskaya fullname: Drutskaya, M.S. email: marinadru@gmail.com organization: Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32475759$$D View this record in MEDLINE/PubMed |
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| Keywords | Anti-cytokine therapeutics SARS-CoV-2 Cytokine release syndrome IL-6 |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
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| Snippet | •COVID-19 severe outcomes is associated with the respiratory failure and cytokine release syndrome with elevated IL-6 as a predicting parameter.•Chronic... Highlights•COVID-19 severe outcomes is associated with the respiratory failure and cytokine release syndrome with elevated IL-6 as a predicting parameter.... COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in... • COVID-19 severe outcomes is associated with the respiratory failure and cytokine release syndrome with elevated IL-6 as a predicting parameter. • Chronic... |
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| SubjectTerms | Advanced Basic Science Anti-cytokine therapeutics Antibodies, Monoclonal, Humanized - therapeutic use Betacoronavirus - drug effects Betacoronavirus - immunology Betacoronavirus - pathogenicity Coronavirus Infections - drug therapy Coronavirus Infections - mortality Coronavirus Infections - pathology COVID-19 Cytokine release syndrome Cytokine Release Syndrome - drug therapy Cytokine Release Syndrome - pathology Cytokine Release Syndrome - virology Humans IL-6 Interleukin-6 - antagonists & inhibitors Interleukin-6 - blood Interleukin-6 - immunology Lung Diseases - immunology Lung Diseases - pathology Lung Diseases - virology Pandemics Pneumonia, Viral - drug therapy Pneumonia, Viral - mortality Pneumonia, Viral - pathology SARS-CoV-2 |
| Title | IL-6: Relevance for immunopathology of SARS-CoV-2 |
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