Population pharmacokinetic analysis of tramadol and O -desmethyltramadol with genetic polymorphism of CYP2D6 - Lee, Joomi; Yoo, Hee-Doo; Bae, Jung-Woo; Lee, Sooyeun; Shin, Kwang-Hee (Drug design, development and therapy, 2019)
Keywords: Administration, Oral; Adult; Analgesics; Analysis; CYP2D6 protein; CYP2D610; Cytochrome; Cytochrome P-450; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P450; Cytochromes P450; Dosage; Dose-Response Relationship, Drug; Enzymes; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Genotype; Healthy Volunteers; Humans; Male; Metabolites; Narcotics; Neuralgia; Nonlinear Dynamics; O-desmethyltramadol; Opioid receptors; Original Research; Pain; Pharmacodynamics; Pharmacokinetics; Pharmacology; Polymorphism; Polymorphism, Genetic - genetics; Population; population model; Republic of Korea; Tramadol; Tramadol - administration & dosage; Tramadol - analogs & derivatives; Tramadol - metabolism; Tramadol - pharmacokinetics; Young Adult; Republic of Korea; Iran; South Korea; United States--US; pharmacokinetics; tramadol; population pharmacokinetic model; CYP2D610; O-desmethyltramadol; genetic polymorphism