Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole

• Published in: Parasites & vectors Vol. 9; no. 186; p. 183
• Main Authors: Andrade-Neto, Valter Viana, Pereira, Thaís Martins, Canto-Cavalheiro, Marilene do, Torres-Santos, Eduardo Caio
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.03.2016; BioMed Central
• Subjects: Animals; Antiprotozoal Agents - pharmacology; Cell Survival - drug effects; Drug Synergism; Drug therapy; Formazans - analysis; Gas Chromatography-Mass Spectrometry; Imipramine; Imipramine - pharmacology; Leishmania mexicana - drug effects; Leishmania mexicana - growth & development; Leishmania mexicana - metabolism; Leishmaniasis; Macrophages, Peritoneal - parasitology; Mice; Miconazole; Miconazole - pharmacology; Observations; Parasitic Sensitivity Tests; Patient outcomes; Short Report; Sterols - analysis; Tetrazolium Salts - analysis; Tetrazolium Salts - metabolism; Thiazoles - metabolism; Sterols; Imipramine; Leishmania

Imipramine, a tricyclic antidepressant widely used clinically, has other pharmacological effects, such as antileishmanial activity. Tricyclic antidepressants interact with lipid bilayers, and some studies have shown that imipramine inhibits methyltransferases. Leishmania spp. produces compounds with...