Disregulation of Leukosialin (CD43, Ly48, Sialophorin) Expression in the B- Cell Lineage of Transgenic Mice Increases Splenic B-Cell Number and Survival

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 92; no. 2; pp. 626 - 630
• Main Authors: Dragone, Leonard L., Barth, Richard K., Sitar, Kristie L., Disbrow, Gary L., Frelinger, John G.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 17.01.1995; National Acad Sciences; National Academy of Sciences
• Subjects: Animals; Antigens, CD; Apoptosis; B lymphocytes; B-Lymphocytes - immunology; Cell Count; Cell Differentiation; Cell lines; Cell Survival; Cellular biology; Cytometry; Enhancer Elements, Genetic - genetics; Flow Cytometry; Gene Expression Regulation; Hematopoietic Stem Cells - immunology; Immunity (Disease); Leukosialin; Mice; Mice, Transgenic; Molecules; Plasma cells; Proteins; Recombinant Fusion Proteins - biosynthesis; Rodents; Sialoglycoproteins - biosynthesis; Spleen; Spleen - cytology; Spleen - immunology; Spleen cells; T lymphocytes; Transgenes

Leukosialin (also known as Ly48, CD43, and sialophorin) is a major cell surface sialoglycoprotein found on a variety of hematopoietically derived cells. The precise function of this molecule is poorly understood but it has been implicated in cell proliferation and intercellular adhesion. We develope...