A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23
Jing Wang, Fengchun Zhang and colleagues report the results of a genome-wide association study of primary Sjögren's syndrome, a common autoimmune disease. They confirm associations in the STAT4 , TNFAIP3 and HLA regions and identify a new susceptibility locus in the GTF2I region at 7q11.23. Pri...
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Published in | Nature genetics Vol. 45; no. 11; pp. 1361 - 1365 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Nature Publishing Group US
01.11.2013
Nature Publishing Group |
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Abstract | Jing Wang, Fengchun Zhang and colleagues report the results of a genome-wide association study of primary Sjögren's syndrome, a common autoimmune disease. They confirm associations in the
STAT4
,
TNFAIP3
and HLA regions and identify a new susceptibility locus in the
GTF2I
region at 7q11.23.
Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjögren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified
GTF2I
at 7q11.23 (rs117026326:
P
combined
= 1.31 × 10
−53
, combined odds ratio (OR
combined
) = 2.20) as a new susceptibility locus for primary Sjögren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of
STAT4
,
TNFAIP3
and the major histocompatibility complex (MHC). Fine mapping of the region around
GTF2I
showed that rs117026326 in
GTF2I
had the most significant association, with associated SNPs extending from
GTF2I
to
GTF2IRD1
-
GTF2I
. |
---|---|
AbstractList | Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjogren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjogren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: P^sub combined^ = 1.31 × 10^sub -53^, combined odds ratio (OR^sub combined^) = 2.20) as a new susceptibility locus for primary Sjogren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of SFAF4, FNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GFF2I showed that rs117026326 in GFF2I had the most significant association, with associated SNPs extending from GFF2I to GFF2IRDI-GFF2I. [PUBLICATION ABSTRACT] Jing Wang, Fengchun Zhang and colleagues report the results of a genome-wide association study of primary Sjögren's syndrome, a common autoimmune disease. They confirm associations in the STAT4 , TNFAIP3 and HLA regions and identify a new susceptibility locus in the GTF2I region at 7q11.23. Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjögren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: P combined = 1.31 × 10 −53 , combined odds ratio (OR combined ) = 2.20) as a new susceptibility locus for primary Sjögren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4 , TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1 - GTF2I . Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjögren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: Pcombined = 1.31 × 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjögren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I. Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjogren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjogren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rsl 17026326: [P.sub.combined] = 1.31 x [10.sup.-53], combined odds ratio ([OR.sub.combined]) = 2.20) as a new susceptibility locus for primary Sjogren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I. Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjogren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjogren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: P sub(combined) = 1.31 10 super(-53), combined odds ratio (OR sub(combined)) = 2.20) as a new susceptibility locus for primary Sjogren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I. Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjögren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: Pcombined = 1.31 × 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjögren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I.Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene approaches. To identify new genetic susceptibility loci for primary Sjögren's syndrome, we performed a three-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 556,134 autosomal SNPs in 542 cases and 1,050 controls. We then validated promising associations in 2 replication stages comprising 1,303 cases and 2,727 controls. The combined analysis identified GTF2I at 7q11.23 (rs117026326: Pcombined = 1.31 × 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjögren's syndrome. Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC). Fine mapping of the region around GTF2I showed that rs117026326 in GTF2I had the most significant association, with associated SNPs extending from GTF2I to GTF2IRD1-GTF2I. |
Audience | Academic |
Author | Li, Zhijun Wang, Li Sun, Lingyun Zhao, Dongbao Zhang, Fengchun Zhang, Liuyan Hou, Yong Shen, Min Shi, Qun Liu, Bin Zhao, Cheng Tong, Shengquan Wu, Huaxiang Xiao, Weiguo Li, Yongzhe Zhang, Wen Zhang, Fengxiao Li, Hongbin Sun, Fei Qi, Wencheng Liu, Wei Liu, Guijian Li, Ping Su, Jinmei Wu, Lijun Zhang, Miaojia Fei, Yunyun Li, Xi Hu, Shaoxian Zhang, Xiao Tian, Xinping Wu, Qingjun Jiang, Ying Zeng, Xiaofeng Zhang, Kunlin Huang, Cibo Xu, Juanjuan Dai, Lie Leng, Xiaomei Zhao, Lidan Zhou, Bin Gong, Huiping Liu, Shengyun Zhang, Xuan Li, Qin Li, Xiaomei Zheng, Wenjie Jiang, Quan Du, Yang Li, Xiangpei You, Xin Ott, Jurg Li, Xiaofeng Chen, Hua Wang, Yongfu Jia, Yuan Zuo, Xiaoxia Zhang, Zhuoli Wu, Min Gong, Lu Li, Mengtao Bi, Liqi Li, Jing Zhang, Xuewu Xu, Jianhua Xu, Dong Zhu, Ping Wang, Jing Hao, Weixin Wang, Yi Luan, Haixia Wang, Guochun Wang, Qian Wu, Ziyan Li, Yang Zhao, Yan |
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surname: Ott fullname: Ott, Jurg organization: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences – sequence: 75 givenname: Jing surname: Wang fullname: Wang, Jing email: wangjing@psych.ac.cn organization: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences – sequence: 76 givenname: Fengchun surname: Zhang fullname: Zhang, Fengchun email: zhangfccra@aliyun.com organization: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24097066$$D View this record in MEDLINE/PubMed |
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Snippet | Jing Wang, Fengchun Zhang and colleagues report the results of a genome-wide association study of primary Sjögren's syndrome, a common autoimmune disease. They... Primary Sjögren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjögren's syndrome have relied mostly on candidate gene... Primary Sjogren's syndrome is one of the most common autoimmune diseases. So far, genetic studies of Sjogren's syndrome have relied mostly on candidate gene... |
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SubjectTerms | 45/43 631/208/205/2138 692/699/249/1313 Agriculture Animal Genetics and Genomics Autoimmune diseases Biomedicine Cancer Research China Chromosome mapping Chromosomes, Human, Pair 7 - genetics Confidence intervals Disease DNA-Binding Proteins - genetics Gene expression Gene Function Genetic aspects Genetic Predisposition to Disease Genetic susceptibility Genome-Wide Association Study Genomes Human Genetics Humans Identification and classification Intracellular Signaling Peptides and Proteins - genetics letter Logistics Major Histocompatibility Complex - genetics Methods Nuclear Proteins - genetics Pathogenesis Polymorphism, Single Nucleotide Quality control Single nucleotide polymorphisms Sjogren's syndrome Sjogren's Syndrome - genetics STAT4 Transcription Factor - genetics Testing Transcription Factors, TFII - genetics Tumor Necrosis Factor alpha-Induced Protein 3 |
Title | A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23 |
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