Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

• Published in: eLife Vol. 5; p. e12661
• Main Authors: Calvo, Margarita, Richards, Natalie, Schmid, Annina B, Barroso, Alejandro, Zhu, Lan, Ivulic, Dinka, Zhu, Ning, Anwandter, Philipp, Bhat, Manzoor A, Court, Felipe A, McMahon, Stephen B, Bennett, David L H
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 19.04.2016; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Action Potentials; Animals; Axons; Axons - physiology; Health aspects; Humans; hypersensitivity; juxtaparanode; Localization; Neural circuitry; Neurons; neuropathic pain; neuropathy; Neuroscience; Pain; Peripheral nerve diseases; Peripheral Nerve Injuries - physiopathology; Peripheral neuropathy; Potassium channels; Potassium channels (voltage-gated); Prevention; Rats; Rodents; Sensory neurons; Shaker Superfamily of Potassium Channels - metabolism; shaker type potassium channels; juxtaparanode; neuropathic pain; hypersensitivity; rat; neuroscience; shaker type potassium channels; neuropathy; human

Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated a...