Regulatory T cell dysfunction in subjects with common variable immunodeficiency complicated by autoimmune disease

• Published in: Clinical immunology (Orlando, Fla.) Vol. 131; no. 2; pp. 240 - 253
• Main Authors: Yu, Grace P., Chiang, David, Song, Steven J., Hoyte, Elisabeth G., Huang, Jennifer, Vanishsarn, Christopher, Nadeau, Kari C.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.05.2009; Elsevier
• Subjects: Adolescent; Adult; Aged; Allergy and Immunology; Autoimmune Diseases - complications; Autoimmune Diseases - immunology; Autoimmune Diseases - physiopathology; Autoimmunity; Biological and medical sciences; Child; Common variable immunodeficiency; Common Variable Immunodeficiency - complications; Common Variable Immunodeficiency - genetics; Common Variable Immunodeficiency - immunology; Common Variable Immunodeficiency - physiopathology; Female; Flow Cytometry; FOXP3 protein, human; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression Regulation; Granzymes; Humans; Immunologic deficiency syndromes; Leukocyte Common Antigens - immunology; Lymphotactin; Male; Middle Aged; Reference Standards; Regulatory; STAT5 transcription factor; T-lymphocytes; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - pathology; TNFRSF18 protein, human; Xcl1 protein, human; Young Adult; Autoimmunity; T-lymphocytes; Common variable immunodeficiency; Granzymes; Xcl1 protein, human; Regulatory; STAT5 transcription factor; TNFRSF18 protein, human; Immunologic deficiency syndromes; Lymphotactin; FOXP3 protein, human; Human; human; FOXP3 protein; Immunopathology; C chemokine; Deficiency; Autoimmune disease; human; STAT5 transcription factor; human; TNFRSF18 protein; Common variable immunodeficiency; T-lymphocytes; Regulatory; Autoimmunity; Immunologic deficiency syndromes; Granzymes; Lymphotactin; Xcl1 protein; Protein; Signal transduction; Immunology; Transcription factor STAT5; Dysfunction; T-Lymphocyte; Complication; Transcription factor; Regulatory cell; Transcription factor FOXP3

Approximately 25% of subjects with common variable immunodeficiency (CVID) develop autoimmune disease. We analyzed T cell subsets, specifically regulatory T cells along with B cell subsets to determine whether there were changes in regulatory T cells which would correlate with the autoimmune disease...