Are brain displacements and pressures within the parenchyma induced by surface pressure differences? A computational modelling study

• Published in: PloS one Vol. 18; no. 12; p. e0288668
• Main Authors: Piersanti, Eleonora, Rognes, Marie E., Vinje, Vegard
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.12.2023
• Subjects: Analysis; Arteries; Biology and Life Sciences; Blood pressure; Blood vessels; Boundary conditions; Brain; Cerebrospinal fluid; Computational neuroscience; Computer simulation; Computer-generated environments; Earth Sciences; Fluid flow; Fluid pressure; Health aspects; Hydrocephalus; Intracranial pressure; Investigations; Medicine and Health Sciences; Parenchyma; Permeability; Physical Sciences; Poroelasticity; Pressure; Pressure gradients; Pulse propagation; Surface pressure; Norway

The intracranial pressure is implicated in many homeostatic processes in the brain and is a fundamental parameter in several diseases such as e.g. idiopathic normal pressure hydrocephalus. The presence of a small but persistent pulsatile intracranial pulsatile transmantle pressure gradient (on the o...