Practical application of toxicogenomics for profiling toxicant-induced biological perturbations

• Published in: International Journal of Molecular Sciences Vol. 11; no. 9; pp. 3397 - 3412
• Main Authors: Kiyosawa, Naoki, Manabe, Sunao, Yamoto, Takashi, Sanbuissho, Atsushi
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 20.09.2010; Molecular Diversity Preservation International (MDPI)
• Subjects: bioinformatics; biomarker; Biomarkers - metabolism; Gene Expression Profiling - methods; Gene Regulatory Networks; microarray; Oligonucleotide Array Sequence Analysis; Review; systems biology; Toxicogenetics - methods; toxicogenomics; Transcriptome; systems biology; microarray; toxicogenomics; biomarker; bioinformatics

A systems-level understanding of molecular perturbations is crucial for evaluating chemical-induced toxicity risks appropriately, and for this purpose comprehensive gene expression analysis or toxicogenomics investigation is highly advantageous. The recent accumulation of toxicity-associated gene se...