Regulation of AMPA receptor trafficking and synaptic plasticity

Highlights ► Highly dynamic trafficking of AMPARs regulates synaptic strength and plasticity. ► Subunit-specific AMPAR interacting proteins regulate receptor trafficking. ► Genetic deletion of AMPAR interacting proteins impairs synaptic plasticity, learning, and memory.

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Bibliographic Details
Published inCurrent opinion in neurobiology Vol. 22; no. 3; pp. 461 - 469
Main Authors Anggono, Victor, Huganir, Richard L
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2012
Subjects
Animals
Models, Biological
Neurology
Neuronal Plasticity - physiology
Protein Transport - physiology
Psychiatry
Receptors, AMPA - metabolism
Synapses - physiology
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Summary:Highlights ► Highly dynamic trafficking of AMPARs regulates synaptic strength and plasticity. ► Subunit-specific AMPAR interacting proteins regulate receptor trafficking. ► Genetic deletion of AMPAR interacting proteins impairs synaptic plasticity, learning, and memory.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2011.12.006