Principal cells of the brainstem's interaural sound level detector are temporal differentiators rather than integrators

The brainstem's lateral superior olive (LSO) is thought to be crucial for localizing high-frequency sounds by coding interaural sound level differences (ILD). Its neurons weigh contralateral inhibition against ipsilateral excitation, making their firing rate a function of the azimuthal position...

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Published ineLife Vol. 7
Main Authors Franken, Tom P, Joris, Philip X, Smith, Philip H
Format Journal Article
LanguageEnglish
Published England eLife Science Publications, Ltd 14.06.2018
eLife Sciences Publications Ltd
eLife Sciences Publications, Ltd
Subjects
Acoustic Stimulation - methods
Action Potentials - physiology
Analysis
Animals
Auditory Pathways - physiology
binaural
Brain stem
Cameras
Detection equipment
Electrodes, Implanted
electron microscopy
Female
Firing rate
Gerbillinae - anatomy & histology
Gerbillinae - physiology
inhibition
Lysine - analogs & derivatives
Lysine - chemistry
Male
Medulla oblongata
Meriones unguiculates
Neural circuitry
Neural coding
Neurons
Neurophysiology
Neuroscience
Olivary Nucleus - anatomy & histology
Olivary Nucleus - cytology
Olivary Nucleus - physiology
patch clamp
Patch-Clamp Techniques
Physiological aspects
Sensory Receptor Cells - cytology
Sensory Receptor Cells - physiology
Sound
Sound Localization - physiology
Staining and Labeling - methods
temporal
United States > US
Meriones unguiculates
patch clamp
binaural
neuroscience
electron microscopy
inhibition
temporal
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Abstract The brainstem's lateral superior olive (LSO) is thought to be crucial for localizing high-frequency sounds by coding interaural sound level differences (ILD). Its neurons weigh contralateral inhibition against ipsilateral excitation, making their firing rate a function of the azimuthal position of a sound source. Since the very first in vivo recordings, LSO principal neurons have been reported to give sustained and temporally integrating 'chopper' responses to sustained sounds. Neurons with transient responses were observed but largely ignored and even considered a sign of pathology. Using the Mongolian gerbil as a model system, we have obtained the first in vivo patch clamp recordings from labeled LSO neurons and find that principal LSO neurons, the most numerous projection neurons of this nucleus, only respond at sound onset and show fast membrane features suggesting an importance for timing. These results provide a new framework to interpret previously puzzling features of this circuit.
AbstractList The brainstem's lateral superior olive (LSO) is thought to be crucial for localizing high-frequency sounds by coding interaural sound level differences (ILD). Its neurons weigh contralateral inhibition against ipsilateral excitation, making their firing rate a function of the azimuthal position of a sound source. Since the very first in vivo recordings, LSO principal neurons have been reported to give sustained and temporally integrating 'chopper' responses to sustained sounds. Neurons with transient responses were observed but largely ignored and even considered a sign of pathology. Using the Mongolian gerbil as a model system, we have obtained the first in vivo patch clamp recordings from labeled LSO neurons and find that principal LSO neurons, the most numerous projection neurons of this nucleus, only respond at sound onset and show fast membrane features suggesting an importance for timing. These results provide a new framework to interpret previously puzzling features of this circuit.
Audience Academic
Author Franken, Tom P
Joris, Philip X
Smith, Philip H
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  givenname: Philip H
  surname: Smith
  fullname: Smith, Philip H
  organization: University of Wisconsin, Madison, United States
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29901438$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1002/cne.902440409
10.1016/j.heares.2010.08.013
10.1121/1.3652890
10.1002/cne.902790305
10.1016/0378-5955(93)90113-F
10.1152/jn.1990.63.5.1169
10.1152/jn.1985.53.1.89
10.1523/JNEUROSCI.08-02-00682.1988
10.1111/j.0953-816X.2003.03133.x
10.1152/jn.1995.73.3.1043
10.1016/B978-0-12-151804-2.50011-5
10.1111/j.1460-9568.1995.tb00697.x
10.3109/00207457209164756
10.1523/JNEUROSCI.1016-05.2005
10.1152/jn.00194.2016
10.1007/s002210050645
10.1152/jn.1968.31.3.442
10.1002/(SICI)1097-0029(19980501)41:3<263::AID-JEMT9>3.0.CO;2-U
10.1002/cne.903040305
10.1002/cne.22411
10.1002/cne.20407
10.1523/JNEUROSCI.12-07-02819.1992
10.1152/jn.00908.2011
10.1152/jn.1977.40.2.296
10.1523/JNEUROSCI.10-11-03494.1990
10.1523/JNEUROSCI.5421-07.2008
10.1152/jn.01087.2010
10.1152/jn.00961.2003
10.1073/pnas.1316216111
10.1016/0006-8993(79)90930-2
10.1152/jn.1988.60.1.1
10.3109/00207457209147165
10.1523/JNEUROSCI.1079-11.2011
10.1177/1073858403252228
10.1523/JNEUROSCI.22-24-11004.2002
10.3389/fncir.2014.00049
10.1002/cne.903310208
10.1523/JNEUROSCI.03-08-01521.1983
10.1523/JNEUROSCI.5433-10.2011
10.1007/BF00238032
10.1371/journal.pone.0029965
10.1002/cne.902690303
10.1121/1.1944647
10.1007/BF00229781
10.1002/cne.10722
10.3389/fncir.2014.00067
10.1016/0378-5955(89)90067-1
10.3389/fncir.2016.00069
10.1002/cne.902320210
10.1371/journal.pone.0075688
10.1152/jn.00911.2009
10.1523/JNEUROSCI.1421-16.2016
10.1177/29.6.7252134
10.1016/0378-5955(88)90054-8
10.1111/j.1460-9568.2009.06925.x
10.1002/aja.1001790108
10.1152/jn.1966.29.4.684
10.1038/nn.2530
10.1016/0378-5955(94)90282-8
10.1002/cne.903190110
10.1002/(SICI)1096-9861(19980105)390:1<20::AID-CNE3>3.0.CO;2-S
10.1371/journal.pcbi.1004997
10.1002/(SICI)1096-9861(19960422)368:1<100::AID-CNE7>3.0.CO;2-7
10.1093/acprof:oso/9780195159561.003.0004
10.1152/jn.2001.86.6.2647
10.1152/jn.00948.2011
10.1523/JNEUROSCI.22-04-01468.2002
10.3389/fnagi.2015.00004
10.1016/0306-4522(82)90228-7
10.1016/0006-8993(90)90698-B
10.1523/JNEUROSCI.2735-08.2008
10.1121/1.1972624
10.1038/nn.3948
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Keywords Meriones unguiculates
patch clamp
binaural
neuroscience
electron microscopy
inhibition
temporal
Language English
License 2018, Franken et al.
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References 30052196 - Elife. 2018 Jul 27;7
Guinan (bib23) 1972; 4
Sanes (bib50) 1990; 10
Cant (bib12) 1991
Geal-Dor (bib17) 1993; 69
Mathews (bib38) 2010; 13
Doucet (bib13) 2003; 461
Kuenzel (bib36) 2011; 31
Spirou (bib57) 1996; 368
Park (bib41) 2004; 92
Boudreau (bib8) 1970; 4
Franken (bib15) 2015; 18
Radtke-Schuller (bib43) 2015; 7
Tsuchitani (bib65) 1966; 29
Smith (bib55) 2005; 482
Kopp-Scheinpflug (bib34) 2002; 22
Greene (bib21) 2012; 108
Irvine (bib28) 2001; 86
Tsuchitani (bib68) 1977; 40
Typlt (bib69) 2012; 7
Glendenning (bib19) 1985; 232
Smith (bib53) 1993; 331
Boudreau (bib7) 1968; 31
Finlayson (bib14) 1989; 38
Sterenborg (bib59) 2010; 270
Banks (bib5) 1992; 12
Hassfurth (bib25) 2009; 30
Walcher (bib71) 2011; 106
Remme (bib44) 2014; 111
Saint Marie (bib47) 1990; 524
Tollin (bib62) 2002; 22
McLaughlin (bib39) 2008; 28
Smith (bib52) 1991; 304
Young (bib76) 1988; 60
Koch (bib33) 1998; 41
Spirou (bib58) 1990; 63
Caird (bib11) 1983; 52
Franken (bib16) 2016; 10
Glendenning (bib18) 1992; 319
Glendenning (bib20) 1983; 3
Moore (bib40) 1988; 269
Sanes (bib49) 1988; 8
Tollin (bib61) 2008; 28
Saint Marie (bib48) 1989; 279
Scott (bib51) 2005; 25
Pollak (bib42) 1988; 36
Khurana (bib32) 2011; 31
Wu (bib74) 1994; 73
Joris (bib29) 1995; 73
Tolbert (bib60) 1982; 7
Rietzel (bib45) 1998; 390
Guinan (bib22) 1972; 4
Young (bib75) 2004
Tsuchitani (bib67) 1991
Brownell (bib10) 1979; 177
Smith (bib54) 2010; 518
Adam (bib1) 1999; 124
Tsai (bib64) 2010; 103
Tsuchitani (bib66) 1969; 46
Roberts (bib46) 2014; 8
Alamilla (bib3) 2013; 8
Kotak (bib35) 2014; 8
Sommer (bib56) 1993; 95
Adams (bib2) 1981; 29
Wright (bib73) 2011; 130
Harnischfeger (bib24) 1985; 53
Brown (bib9) 2016; 36
Viemeister (bib70) 1993
Helfert (bib27) 1987; 179
Jurkovičová-Tarabová (bib30) 2012; 108
Wei (bib72) 2017; 118
Barnes-Davies (bib6) 2004; 19
Maki (bib37) 2005; 118
Kandler (bib31) 1995; 7
Tollin (bib63) 2003; 9
Ashida (bib4) 2016; 12
Helfert (bib26) 1986; 244
References_xml – volume: 244
  start-page: 533
  year: 1986
  ident: bib26
  article-title: Morphological evidence for the existence of multiple neuronal classes in the cat lateral superior olivary nucleus
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.902440409
  contributor:
    fullname: Helfert
– volume: 270
  start-page: 119
  year: 2010
  ident: bib59
  article-title: Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons
  publication-title: Hearing Research
  doi: 10.1016/j.heares.2010.08.013
  contributor:
    fullname: Sterenborg
– volume: 130
  start-page: 3545
  year: 2011
  ident: bib73
  article-title: An exact method of regularity analysis for auditory brainstem neurons (L)
  publication-title: The Journal of the Acoustical Society of America
  doi: 10.1121/1.3652890
  contributor:
    fullname: Wright
– volume: 279
  start-page: 382
  year: 1989
  ident: bib48
  article-title: Glycine-immunoreactive projection of the cat lateral superior olive: possible role in midbrain ear dominance
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.902790305
  contributor:
    fullname: Saint Marie
– volume: 69
  start-page: 236
  year: 1993
  ident: bib17
  article-title: Development of hearing in neonatal rats: air and bone conducted ABR thresholds
  publication-title: Hearing Research
  doi: 10.1016/0378-5955(93)90113-F
  contributor:
    fullname: Geal-Dor
– volume: 63
  start-page: 1169
  year: 1990
  ident: bib58
  article-title: Recordings from cat trapezoid body and HRP labeling of globular bushy cell axons
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.1990.63.5.1169
  contributor:
    fullname: Spirou
– volume: 53
  start-page: 89
  year: 1985
  ident: bib24
  article-title: Interaural time and intensity coding in superior olivary complex and inferior colliculus of the echolocating bat Molossus ater
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.1985.53.1.89
  contributor:
    fullname: Harnischfeger
– volume: 8
  start-page: 682
  year: 1988
  ident: bib49
  article-title: The ontogeny of inhibition and excitation in the gerbil lateral superior olive
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.08-02-00682.1988
  contributor:
    fullname: Sanes
– volume: 19
  start-page: 325
  year: 2004
  ident: bib6
  article-title: Kv1 currents mediate a gradient of principal neuron excitability across the tonotopic axis in the rat lateral superior olive
  publication-title: European Journal of Neuroscience
  doi: 10.1111/j.0953-816X.2003.03133.x
  contributor:
    fullname: Barnes-Davies
– volume: 73
  start-page: 1043
  year: 1995
  ident: bib29
  article-title: Envelope coding in the lateral superior olive. I. Sensitivity to interaural time differences
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.1995.73.3.1043
  contributor:
    fullname: Joris
– volume: 4
  start-page: 143
  year: 1970
  ident: bib8
  article-title: Cat superior olive S-segment cell discharge to tonal stimulation
  publication-title: Contributions to Sensory Physiology
  doi: 10.1016/B978-0-12-151804-2.50011-5
  contributor:
    fullname: Boudreau
– volume: 7
  start-page: 1773
  year: 1995
  ident: bib31
  article-title: Development of electrical membrane properties and discharge characteristics of superior olivary complex neurons in fetal and postnatal rats
  publication-title: European Journal of Neuroscience
  doi: 10.1111/j.1460-9568.1995.tb00697.x
  contributor:
    fullname: Kandler
– volume: 4
  start-page: 147
  year: 1972
  ident: bib23
  article-title: Single auditory units in the superior olivary complex: ii: locations of unit categories and tonotopic organization
  publication-title: International Journal of Neuroscience
  doi: 10.3109/00207457209164756
  contributor:
    fullname: Guinan
– volume: 25
  start-page: 7887
  year: 2005
  ident: bib51
  article-title: Posthearing developmental refinement of temporal processing in principal neurons of the medial superior olive
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.1016-05.2005
  contributor:
    fullname: Scott
– volume: 118
  start-page: 2009
  year: 2017
  ident: bib72
  article-title: Enhancement of phase-locking in rodents. I. An axonal recording study in gerbil
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.00194.2016
  contributor:
    fullname: Wei
– volume: 124
  start-page: 489
  year: 1999
  ident: bib1
  article-title: Firing properties of chopper and delay neurons in the lateral superior olive of the rat
  publication-title: Experimental Brain Research
  doi: 10.1007/s002210050645
  contributor:
    fullname: Adam
– volume: 31
  start-page: 442
  year: 1968
  ident: bib7
  article-title: Binaural interaction in the cat superior olive S segment
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.1968.31.3.442
  contributor:
    fullname: Boudreau
– volume: 41
  start-page: 263
  year: 1998
  ident: bib33
  article-title: Afferent regulation of glycine receptor distribution in the gerbil LSO
  publication-title: Microscopy Research and Technique
  doi: 10.1002/(SICI)1097-0029(19980501)41:3<263::AID-JEMT9>3.0.CO;2-U
  contributor:
    fullname: Koch
– volume: 304
  start-page: 387
  year: 1991
  ident: bib52
  article-title: Projections of physiologically characterized globular bushy cell axons from the cochlear nucleus of the cat
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.903040305
  contributor:
    fullname: Smith
– volume: 518
  start-page: 3679
  year: 2010
  ident: bib54
  article-title: Evaluation of inputs to rat primary auditory cortex from the suprageniculate nucleus and extrastriate visual cortex
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.22411
  contributor:
    fullname: Smith
– volume: 482
  start-page: 349
  year: 2005
  ident: bib55
  article-title: Acoustic stria: anatomy of physiologically characterized cells and their axonal projection patterns
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.20407
  contributor:
    fullname: Smith
– volume: 12
  start-page: 2819
  year: 1992
  ident: bib5
  article-title: Intracellular recordings from neurobiotin-labeled cells in brain slices of the rat medial nucleus of the trapezoid body
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.12-07-02819.1992
  contributor:
    fullname: Banks
– volume: 108
  start-page: 1942
  year: 2012
  ident: bib21
  article-title: Discharge patterns in the lateral superior olive of decerebrate cats
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.00908.2011
  contributor:
    fullname: Greene
– volume: 40
  start-page: 296
  year: 1977
  ident: bib68
  article-title: Functional organization of lateral cell groups of cat superior olivary complex
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.1977.40.2.296
  contributor:
    fullname: Tsuchitani
– volume: 10
  start-page: 3494
  year: 1990
  ident: bib50
  article-title: An in vitro analysis of sound localization mechanisms in the gerbil lateral superior olive
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.10-11-03494.1990
  contributor:
    fullname: Sanes
– volume: 28
  start-page: 4848
  year: 2008
  ident: bib61
  article-title: Interaural level difference discrimination thresholds for single neurons in the lateral superior olive
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.5421-07.2008
  contributor:
    fullname: Tollin
– volume: 106
  start-page: 1443
  year: 2011
  ident: bib71
  article-title: Comparative posthearing development of inhibitory inputs to the lateral superior olive in gerbils and mice
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.01087.2010
  contributor:
    fullname: Walcher
– volume: 92
  start-page: 289
  year: 2004
  ident: bib41
  article-title: Interaural level difference processing in the lateral superior olive and the inferior colliculus
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.00961.2003
  contributor:
    fullname: Park
– volume: 111
  start-page: E2339
  year: 2014
  ident: bib44
  article-title: Subthreshold resonance properties contribute to the efficient coding of auditory spatial cues
  publication-title: PNAS
  doi: 10.1073/pnas.1316216111
  contributor:
    fullname: Remme
– start-page: 116
  volume-title: Human PsychophysicsSpringer Handbook of Auditory Research
  year: 1993
  ident: bib70
  contributor:
    fullname: Viemeister
– volume: 177
  start-page: 189
  year: 1979
  ident: bib10
  article-title: Ipsilateral inhibitory responses in the cat lateral superior olive
  publication-title: Brain Research
  doi: 10.1016/0006-8993(79)90930-2
  contributor:
    fullname: Brownell
– volume: 60
  start-page: 1
  year: 1988
  ident: bib76
  article-title: Regularity and latency of units in ventral cochlear nucleus: implications for unit classification and generation of response properties
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.1988.60.1.1
  contributor:
    fullname: Young
– volume: 4
  start-page: 101
  year: 1972
  ident: bib22
  article-title: Single auditory units in the superior olivary complex: i: responses to sounds and classifications based on physiological properties
  publication-title: International Journal of Neuroscience
  doi: 10.3109/00207457209147165
  contributor:
    fullname: Guinan
– volume: 31
  start-page: 8936
  year: 2011
  ident: bib32
  article-title: Dynamic interaction of Ih and IK-LVA during trains of synaptic potentials in principal neurons of the medial superior olive
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.1079-11.2011
  contributor:
    fullname: Khurana
– volume: 9
  start-page: 127
  year: 2003
  ident: bib63
  article-title: The lateral superior olive: a functional role in sound source localization
  publication-title: The Neuroscientist
  doi: 10.1177/1073858403252228
  contributor:
    fullname: Tollin
– volume: 22
  start-page: 11004
  year: 2002
  ident: bib34
  article-title: Interaction of excitation and inhibition in anteroventral cochlear nucleus neurons that receive large endbulb synaptic endings
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.22-24-11004.2002
  contributor:
    fullname: Kopp-Scheinpflug
– volume: 8
  start-page: 49
  year: 2014
  ident: bib46
  article-title: The relative contributions of MNTB and LNTB neurons to inhibition in the medial superior olive assessed through single and paired recordings
  publication-title: Frontiers in Neural Circuits
  doi: 10.3389/fncir.2014.00049
  contributor:
    fullname: Roberts
– volume: 331
  start-page: 245
  year: 1993
  ident: bib53
  article-title: Projections of physiologically characterized spherical bushy cell axons from the cochlear nucleus of the cat: evidence for delay lines to the medial superior olive
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.903310208
  contributor:
    fullname: Smith
– volume: 3
  start-page: 1521
  year: 1983
  ident: bib20
  article-title: Acoustic chiasm: efferent projections of the lateral superior olive
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.03-08-01521.1983
  contributor:
    fullname: Glendenning
– volume: 31
  start-page: 4260
  year: 2011
  ident: bib36
  article-title: Factors controlling the input-output relationship of spherical bushy cells in the gerbil cochlear nucleus
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.5433-10.2011
  contributor:
    fullname: Kuenzel
– volume: 52
  start-page: 385
  year: 1983
  ident: bib11
  article-title: Processing of binaural stimuli by cat superior olivary complex neurons
  publication-title: Experimental Brain Research
  doi: 10.1007/BF00238032
  contributor:
    fullname: Caird
– volume: 7
  start-page: e29965
  year: 2012
  ident: bib69
  article-title: Multidimensional characterization and differentiation of neurons in the anteroventral cochlear nucleus
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0029965
  contributor:
    fullname: Typlt
– volume: 269
  start-page: 342
  year: 1988
  ident: bib40
  article-title: Auditory brainstem of the ferret: sources of projections to the inferior colliculus
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.902690303
  contributor:
    fullname: Moore
– volume: 118
  start-page: 872
  year: 2005
  ident: bib37
  article-title: Acoustical cues for sound localization by the mongolian gerbil, Meriones unguiculatus
  publication-title: The Journal of the Acoustical Society of America
  doi: 10.1121/1.1944647
  contributor:
    fullname: Maki
– volume: 95
  start-page: 223
  year: 1993
  ident: bib56
  article-title: Principal cells of the rat medial nucleus of the trapezoid body: an intracellular in vivo study of their physiology and morphology
  publication-title: Experimental Brain Research
  doi: 10.1007/BF00229781
  contributor:
    fullname: Sommer
– volume: 461
  start-page: 452
  year: 2003
  ident: bib13
  article-title: Axonal pathways to the lateral superior olive labeled with biotinylated dextran amine injections in the dorsal cochlear nucleus of rats
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.10722
  contributor:
    fullname: Doucet
– volume: 8
  start-page: 67
  year: 2014
  ident: bib35
  article-title: Developmental expression of inhibitory synaptic long-term potentiation in the lateral superior olive
  publication-title: Frontiers in Neural Circuits
  doi: 10.3389/fncir.2014.00067
  contributor:
    fullname: Kotak
– volume: 38
  start-page: 221
  year: 1989
  ident: bib14
  article-title: Synaptic potentials of chinchilla lateral superior olivary neurons
  publication-title: Hearing Research
  doi: 10.1016/0378-5955(89)90067-1
  contributor:
    fullname: Finlayson
– volume: 10
  start-page: 69
  year: 2016
  ident: bib16
  article-title: In vivo whole-cell recordings combined with electron microscopy reveal unexpected morphological and physiological properties in the lateral nucleus of the trapezoid body in the auditory brainstem
  publication-title: Frontiers in Neural Circuits
  doi: 10.3389/fncir.2016.00069
  contributor:
    fullname: Franken
– volume: 232
  start-page: 261
  year: 1985
  ident: bib19
  article-title: Acoustic chiasm II: anatomical basis of binaurality in lateral superior olive of cat
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.902320210
  contributor:
    fullname: Glendenning
– volume: 8
  start-page: e75688
  year: 2013
  ident: bib3
  article-title: Maturation of calcium-dependent GABA, glycine, and glutamate release in the glycinergic MNTB-LSO pathway
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0075688
  contributor:
    fullname: Alamilla
– volume: 103
  start-page: 875
  year: 2010
  ident: bib64
  article-title: Varying overall sound intensity to the two ears impacts interaural level difference discrimination thresholds by single neurons in the lateral superior olive
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.00911.2009
  contributor:
    fullname: Tsai
– volume: 36
  start-page: 9908
  year: 2016
  ident: bib9
  article-title: Slow temporal integration enables robust neural coding and perception of a cue to sound source location
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.1421-16.2016
  contributor:
    fullname: Brown
– volume: 29
  start-page: 775
  year: 1981
  ident: bib2
  article-title: Heavy metal intensification of DAB-based HRP reaction product
  publication-title: Journal of Histochemistry & Cytochemistry
  doi: 10.1177/29.6.7252134
  contributor:
    fullname: Adams
– volume: 36
  start-page: 107
  year: 1988
  ident: bib42
  article-title: Time is traded for intensity in the bat's auditory system
  publication-title: Hearing Research
  doi: 10.1016/0378-5955(88)90054-8
  contributor:
    fullname: Pollak
– volume: 30
  start-page: 1227
  year: 2009
  ident: bib25
  article-title: Sensory deprivation regulates the development of the hyperpolarization-activated current in auditory brainstem neurons
  publication-title: European Journal of Neuroscience
  doi: 10.1111/j.1460-9568.2009.06925.x
  contributor:
    fullname: Hassfurth
– start-page: 99
  volume-title: Neurobiology of Hearing: The Central Auditory System
  year: 1991
  ident: bib12
  contributor:
    fullname: Cant
– volume: 179
  start-page: 55
  year: 1987
  ident: bib27
  article-title: Morphological features of five neuronal classes in the gerbil lateral superior olive
  publication-title: American Journal of Anatomy
  doi: 10.1002/aja.1001790108
  contributor:
    fullname: Helfert
– volume: 29
  start-page: 684
  year: 1966
  ident: bib65
  article-title: Single unit analysis of cat superior olive S segment with tonal stimuli
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.1966.29.4.684
  contributor:
    fullname: Tsuchitani
– volume: 13
  start-page: 601
  year: 2010
  ident: bib38
  article-title: Control of submillisecond synaptic timing in binaural coincidence detectors by K(v)1 channels
  publication-title: Nature Neuroscience
  doi: 10.1038/nn.2530
  contributor:
    fullname: Mathews
– volume: 73
  start-page: 57
  year: 1994
  ident: bib74
  article-title: Physiological evidence for ipsilateral inhibition in the lateral superior olive: synaptic responses in mouse brain slice
  publication-title: Hearing Research
  doi: 10.1016/0378-5955(94)90282-8
  contributor:
    fullname: Wu
– volume: 319
  start-page: 100
  year: 1992
  ident: bib18
  article-title: Acoustic chiasm V: inhibition and excitation in the ipsilateral and contralateral projections of LSO
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/cne.903190110
  contributor:
    fullname: Glendenning
– volume: 390
  start-page: 20
  year: 1998
  ident: bib45
  article-title: Neuron types in the rat lateral superior olive and developmental changes in the complexity of their dendritic arbors
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/(SICI)1096-9861(19980105)390:1<20::AID-CNE3>3.0.CO;2-S
  contributor:
    fullname: Rietzel
– volume: 12
  start-page: e1004997
  year: 2016
  ident: bib4
  article-title: Roles for coincidence detection in coding Amplitude-Modulated sounds
  publication-title: PLOS Computational Biology
  doi: 10.1371/journal.pcbi.1004997
  contributor:
    fullname: Ashida
– volume: 368
  start-page: 100
  year: 1996
  ident: bib57
  article-title: Organization of ventrolateral periolivary cells of the cat superior olive as revealed by PEP-19 immunocytochemistry and Nissl stain
  publication-title: The Journal of Comparative Neurology
  doi: 10.1002/(SICI)1096-9861(19960422)368:1<100::AID-CNE7>3.0.CO;2-7
  contributor:
    fullname: Spirou
– start-page: 125
  volume-title: The Synaptic Organization of the Brain
  year: 2004
  ident: bib75
  doi: 10.1093/acprof:oso/9780195159561.003.0004
  contributor:
    fullname: Young
– volume: 86
  start-page: 2647
  year: 2001
  ident: bib28
  article-title: Mechanisms underlying the sensitivity of neurons in the lateral superior olive to interaural intensity differences
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.2001.86.6.2647
  contributor:
    fullname: Irvine
– volume: 108
  start-page: 365
  year: 2012
  ident: bib30
  article-title: Repertoire of high voltage-activated Ca2+ channels in the lateral superior olive: functional analysis in wild-type, ca(v)1.3(-/-), and ca(v)1.2DHP(-/-) mice
  publication-title: Journal of Neurophysiology
  doi: 10.1152/jn.00948.2011
  contributor:
    fullname: Jurkovičová-Tarabová
– volume: 22
  start-page: 1468
  year: 2002
  ident: bib62
  article-title: The coding of spatial location by single units in the lateral superior olive of the cat. II. The determinants of spatial receptive fields in azimuth
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.22-04-01468.2002
  contributor:
    fullname: Tollin
– volume: 7
  start-page: 4
  year: 2015
  ident: bib43
  article-title: Restricted loss of olivocochlear but not vestibular efferent neurons in the senescent gerbil (Meriones unguiculatus)
  publication-title: Frontiers in Aging Neuroscience
  doi: 10.3389/fnagi.2015.00004
  contributor:
    fullname: Radtke-Schuller
– volume: 7
  start-page: 3031
  year: 1982
  ident: bib60
  article-title: The neuronal architecture of the anteroventral cochlear nucleus of the cat in the region of the cochlear nerve root: horseradish peroxidase labelling of identified cell types
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(82)90228-7
  contributor:
    fullname: Tolbert
– start-page: 163
  volume-title: Neurobiology of Hearing: The Central Auditory System
  year: 1991
  ident: bib67
  contributor:
    fullname: Tsuchitani
– volume: 524
  start-page: 244
  year: 1990
  ident: bib47
  article-title: Neurotransmitter-specific uptake and retrograde transport of [3H]glycine from the inferior colliculus by ipsilateral projections of the superior olivary complex and nuclei of the lateral lemniscus
  publication-title: Brain Research
  doi: 10.1016/0006-8993(90)90698-B
  contributor:
    fullname: Saint Marie
– volume: 28
  start-page: 10206
  year: 2008
  ident: bib39
  article-title: How secure is in vivo synaptic transmission at the calyx of Held?
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.2735-08.2008
  contributor:
    fullname: McLaughlin
– volume: 46
  start-page: 113
  year: 1969
  ident: bib66
  article-title: Stimulus level of dichotically presented tones and cat superior olive S-segment cell dcharge
  publication-title: The Journal of the Acoustical Society of America
  doi: 10.1121/1.1972624
  contributor:
    fullname: Tsuchitani
– volume: 18
  start-page: 444
  year: 2015
  ident: bib15
  article-title: In vivo coincidence detection in mammalian sound localization generates phase delays
  publication-title: Nature Neuroscience
  doi: 10.1038/nn.3948
  contributor:
    fullname: Franken
SSID ssj0000748819
Score 2.4450812
Snippet The brainstem's lateral superior olive (LSO) is thought to be crucial for localizing high-frequency sounds by coding interaural sound level differences (ILD)....
The brainstem’s lateral superior olive (LSO) is thought to be crucial for localizing high-frequency sounds by coding interaural sound level differences (ILD)....
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pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
SubjectTerms Acoustic Stimulation - methods
Action Potentials - physiology
Analysis
Animals
Auditory Pathways - physiology
binaural
Brain stem
Cameras
Detection equipment
Electrodes, Implanted
electron microscopy
Female
Firing rate
Gerbillinae - anatomy & histology
Gerbillinae - physiology
inhibition
Lysine - analogs & derivatives
Lysine - chemistry
Male
Medulla oblongata
Meriones unguiculates
Neural circuitry
Neural coding
Neurons
Neurophysiology
Neuroscience
Olivary Nucleus - anatomy & histology
Olivary Nucleus - cytology
Olivary Nucleus - physiology
patch clamp
Patch-Clamp Techniques
Physiological aspects
Sensory Receptor Cells - cytology
Sensory Receptor Cells - physiology
Sound
Sound Localization - physiology
Staining and Labeling - methods
temporal
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Title Principal cells of the brainstem's interaural sound level detector are temporal differentiators rather than integrators
URI https://www.ncbi.nlm.nih.gov/pubmed/29901438
https://www.proquest.com/docview/2097958921
https://search.proquest.com/docview/2055615703
https://pubmed.ncbi.nlm.nih.gov/PMC6063729
https://doaj.org/article/6d2b57f34c804abfa7852d4e2216e4b1
Volume 7
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