Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

• Published in: Nature cell biology Vol. 21; no. 1; pp. 9 - 17
• Main Authors: Mathieu, Mathilde, Martin-Jaular, Lorena, Lavieu, Grégory, Théry, Clotilde
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2019; Nature Publishing Group
• Subjects: 631/80/313; 631/80/86/820; Actin Cytoskeleton - metabolism; Analysis; Biological Transport; Biology; Biomedical and Life Sciences; Biosynthesis; Cancer Research; Cell Biology; Cell Communication; Cell interactions; Cell Membrane - metabolism; Cell membranes; Communication; Developmental Biology; Exosomes; Exosomes - metabolism; Extracellular vesicles; Extracellular Vesicles - metabolism; Humans; Life Sciences; Lipids; Lipoproteins; Membrane lipids; Models, Biological; Organelle biogenesis; Perspective; Plasma; Proteins; Stem Cells; Universities and colleges; Vesicles

The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from other extracellular vesicles in terms of their biogenesis and...