Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

• Published in: Nature medicine Vol. 25; no. 4; pp. 554 - 560
• Main Authors: Moreno-Jiménez, Elena P., Flor-García, Miguel, Terreros-Roncal, Julia, Rábano, Alberto, Cafini, Fabio, Pallas-Bazarra, Noemí, Ávila, Jesús, Llorens-Martín, María
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2019; Nature Publishing Group
• Subjects: 631/378/1689/1283; 631/378/368/2431; 692/617/375/365/1283; Adult; Adults; Advertising executives; Aging; Alzheimer Disease - pathology; Alzheimer's disease; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Brain; Cancer Research; Care and treatment; Cell Differentiation; Controlled conditions; Dentate gyrus; Dentate Gyrus - pathology; Development and progression; Doublecortin Domain Proteins; Hippocampal plasticity; Hippocampus; Hippocampus - pathology; Humans; Identification methods; Infectious Diseases; Letter; Maturation; Metabolic Diseases; Microtubule-Associated Proteins - metabolism; Molecular Medicine; Neurogenesis; Neurons; Neuropeptides - metabolism; Neurosciences; Novels; Physiology; Psychological aspects; Resveratrol

The hippocampus is one of the most affected areas in Alzheimer’s disease (AD) 1 . Moreover, this structure hosts one of the most unique phenomena of the adult mammalian brain, namely, the addition of new neurons throughout life 2 . This process, called adult hippocampal neurogenesis (AHN), confers a...