Mrgprb2-mediated mast cell activation exacerbates Modic changes by regulating immune niches

• Published in: Experimental & molecular medicine Vol. 56; no. 5; pp. 1178 - 1192
• Main Authors: Ji, Zhongyin, Li, Jie, Tao, Siyue, Li, Hui, Kong, Xiangxi, Huang, Bao, Feng, Zhenhua, Wei, Xiaoan, Zheng, Zeyu, Chen, Jian, Chen, Binhui, Liu, Junhui, Zhao, Fengdong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2024; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 1-Phosphatidylinositol 3-kinase; 13; 13/1; 13/51; 13/95; 14/35; 14/63; 38; 38/1; 38/91; 42; 45/91; 631/250/2504/223/1630; 64/110; 64/60; 692/698/1671/1354; 82; 82/1; 82/29; 96/95; AKT protein; Animal models; Animals; Artificial intelligence; Bacteria; Biomedical and Life Sciences; Biomedicine; Bone marrow; Cartilage; Cell activation; Cell culture; Chronic infection; Compound 48/80; Disease Models, Animal; Female; Hospitals; Humans; Immune response; Infiltration; Inflammation; Intervertebral Disc Degeneration - genetics; Intervertebral Disc Degeneration - immunology; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; Intervertebral discs; Macrophages; Magnetic resonance imaging; Male; MAP kinase; Mast cells; Mast Cells - immunology; Mast Cells - metabolism; Medical Biochemistry; Mice; Mice, Knockout; Middle Aged; Molecular Medicine; Orthopedics; Polarization; Quality of life; Signal Transduction; Stem Cells; Surgery; Therapeutic targets; Transcriptomics; Vertebrae; Virulence; 생화학

Modic changes are radiographic features associated with microfracture, low-virulence organism infection and chronic inflammation with inflammatory cell infiltration in the vertebral endplate region. Mast cells, as innate immune cells similar to macrophages, are present in painful degenerated interve...