Bitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders

• Published in: Drug design, development and therapy Vol. 15; pp. 895 - 903
• Main Authors: Cheng, Weyland, Yao, Manye, Liu, Fangna
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2021; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Anti-Inflammatory Agents - pharmacology; Bacteria; Biofilms; Biomedical materials; Bitter taste; Bone growth; bone inflammation; Bone resorption; Calcium; Calcium (intracellular); Calcium (reticular); calcium signaling; Cell activation; Disorders; drug target; Endoplasmic reticulum; Genotype & phenotype; Gram-negative bacteria; Gram-positive bacteria; Granulocytes; Health aspects; Histamine; Homeostasis; Humans; Hypothesis; Immune system; Immunotherapy; Inflammation; Innate immunity; Inositol trisphosphate; Intracellular; Kinases; Molecular Structure; Musculoskeletal Diseases - drug therapy; Musculoskeletal Diseases - immunology; Nitric oxide; Orthopedics; Osteitis - drug therapy; Osteitis - immunology; osteoblasts; Osteoclasts; Osteocytes; Osteogenesis; Phospholipase C; Proteins; Receptors; Receptors, G-Protein-Coupled - antagonists & inhibitors; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - immunology; tas2r; Taste; Taste receptors; Tumor necrosis factor-TNF; TAS2R; bone inflammation; osteoblasts; drug target; calcium signaling

Non-gustatory, extraoral bitter taste receptors (T2Rs) are G-protein coupled receptors that are expressed throughout the body and have various functional responses when stimulated by bitter agonists. Presently, T2Rs have been found to be expressed in osteoclasts and osteocytes where osteoclasts were...