Glycine plays a crucial role as a co-agonist of NMDA receptors in the neuronal circuit generating body movements in rat fetuses

• Published in: Neuroscience research Vol. 97; pp. 13 - 19
• Main Authors: Shimomura, Hideki, Ito, Mari, Nishiyama, Ayae, Tanizawa, Takakuni, Takeshima, Yasuhiro, Nishimaru, Hiroshi, Arata, Akiko
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.08.2015
• Subjects: Action Potentials; Animals; Animals, Newborn; Brain Stem - physiology; Brainstem-spinal cord preparation; Fetal movement; Fetus - physiology; Glycine - physiology; Movement; Neural Pathways - physiology; Neurons - physiology; NMDA receptor glycine binding site; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate - agonists; Receptors, N-Methyl-D-Aspartate - physiology; Spinal Cord - physiology; Strychnine; Strychnine; NMDA receptor glycine binding site; Fetal movement; Brainstem-spinal cord preparation

•We examined the contribution of glycine to the perinatal rat spinal circuit.•We used isolated brainstem-spinal cord-upper limb preparation from perinatal rat.•We focused on the developmental changes of forelimb movements as a fetal movement.•Glycine generated fetal movement via the glycine binding...