Thioacetamide accelerates steatohepatitis, cirrhosis and HCC by expressing HCV core protein in transgenic zebrafish Danio rerio

• Published in: Toxicology (Amsterdam) Vol. 243; no. 1; pp. 11 - 22
• Main Authors: Rekha, Ravikumar Deepa, Amali, Aseervatham Anusha, Her, Gour Mour, Yeh, Yang Hui, Gong, Hong-Yi, Hu, Shao-Yang, Lin, Gen-Hwa, Wu, Jen-Leih
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 14.01.2008; Amsterdam Elsevier Science
• Subjects: Animals; Animals, Genetically Modified; Biological and medical sciences; Carcinoma, Hepatocellular - chemically induced; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - virology; Chemical and Drug Induced Liver Injury; Danio rerio; DNA Primers; Emergency; Fatty Liver - chemically induced; Fatty Liver - genetics; Fatty Liver - virology; Gastroenterology. Liver. Pancreas. Abdomen; Hepacivirus - genetics; Hepatitis C virus; Hepatocellular carcinoma; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver Cirrhosis - chemically induced; Liver Cirrhosis - genetics; Liver Cirrhosis - virology; Liver Diseases - genetics; Liver Diseases - virology; Liver Neoplasms - chemically induced; Liver Neoplasms - genetics; Liver Neoplasms - virology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Microscopy, Confocal; Other diseases. Semiology; Reverse Transcriptase Polymerase Chain Reaction; Thioacetamide; Thioacetamide - toxicity; Toxicology; Tumors; Viral Core Proteins - genetics; Zebrafish; Zebrafish - genetics; thioacetamide; HCP; TAA; hepatitis C virus; HCC; Zebrafish; HCV; hepatocellular carcinoma; hepatitis C virus core protein; Thioacetamide; Hepatocellular carcinoma; Digestive system; Liver; Hepatic disease; Malignant tumor; Protein; Steatosis; Virus; Liver cancer; Cirrhosis; Vertebrata; Brachydanio rerio; Pisces; Digestive diseases; Flaviviridae; Hepatitis C virus; Hepacivirus; Cancer

Abstract Hepatocellular carcinoma (HCC) is one of the common cancers worldwide, caused by Hepatitis C virus (HCV) and hepatotoxins. Here we report the development of HCC in wild type as well as HCV core protein (HCP)-transgenic zebrafish upon treatment with a hepatotoxin, thioacetamide (TAA). Two-fo...