Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

• Published in: Cell Vol. 148; no. 3; pp. 434 - 446
• Main Authors: Tobin, David M., Roca, Francisco J., Oh, Sungwhan F., McFarland, Ross, Vickery, Thad W., Ray, John P., Ko, Dennis C., Zou, Yuxia, Bang, Nguyen D., Chau, Tran T.H., Vary, Jay C., Hawn, Thomas R., Dunstan, Sarah J., Farrar, Jeremy J., Thwaites, Guy E., King, Mary-Claire, Serhan, Charles N., Ramakrishnan, Lalita
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.02.2012
• Subjects: Animals; Danio rerio; Disease Models, Animal; eicosanoids; genotype; Humans; immune response; inflammation; Inflammation - immunology; Leukotriene A4 - genetics; Leukotriene A4 - immunology; Leukotriene B4 - genetics; Leukotriene B4 - immunology; Lipoxins - immunology; loci; meningitis; Mitochondria - metabolism; Mycobacterium; Mycobacterium Infections - drug therapy; Mycobacterium Infections - genetics; Mycobacterium Infections - immunology; Mycobacterium marinum; patients; polymorphism; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Signal Transduction; single nucleotide polymorphism; therapeutics; transcription (genetics); Transcription, Genetic; tuberculosis; Tuberculosis, Meningeal - drug therapy; Tuberculosis, Meningeal - genetics; Tuberculosis, Meningeal - immunology; Tumor Necrosis Factor-alpha - metabolism; tumor necrosis factors; Zebrafish - embryology; Zebrafish - immunology

Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to Mycobacterium marinum can result from either inadequate or excessive acute inflammation. Modulation of the leukotriene A...