Antitumor effect of radioactive cisplatin ( 191Pt) on nude mice

• Published in: International journal of radiation oncology, biology, physics Vol. 49; no. 3; pp. 827 - 832
• Main Authors: Areberg, Johan, Wennerberg, Johan, Johnsson, Anders, Norrgren, Kristina, Mattsson, Sören
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2001; Elsevier
• Subjects: 191Pt-cisplatin; Animals; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Body Weight - drug effects; Body Weight - radiation effects; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - radiotherapy; Cisplatin; Cisplatin - therapeutic use; Clinical Medicine; Combined Modality Therapy - methods; Combined treatment; Drug Combinations; Drug Screening Assays, Antitumor; Female; Humans; Klinisk medicin; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Mice; Mice, Inbred BALB C; Mice, Nude; Platinum - therapeutic use; Radiation-Sensitizing Agents - therapeutic use; Radiochemotherapy; Radioisotopes - therapeutic use; Radiologi och bildbehandling; Radiology, Nuclear Medicine and Medical Imaging; Transplantation, Heterologous; Treatment. General aspects; Tumors; 191Pt-cisplatin; Mice; Cisplatin; Radiochemotherapy; Antineoplastic agent; Evaluation; Animal model; Radiolabelling; Toxicity; Treatment efficiency; Mortality; Rodentia; Malignant tumor; Experimental study; Chemoradiotherapy; Vertebrata; Chemotherapy; Mammalia; Mouse; Platinum; Animal; Platinum II Complexes
• ISSN: 0360-3016; 1879-355X
• DOI: 10.1016/S0360-3016(00)01419-X

Purpose: To investigate the effect of 191Pt-cisplatin in vivo in terms of the antitumor effect and general toxicity on tumor-bearing nude mice. Methods and Materials: Tumor-bearing (human squamous cell carcinoma, ÅB) nude mice were divided into four groups and given, i.p., physiological saline (controls), cisplatin, 191Pt-cisplatin (80 MBq/mg), or 191Pt-cisplatin (160 MBq/mg), respectively. Mortality and weight were used as parameters for monitoring general toxic effect, while specific growth delay (SGD) and the area under the logarithm of the relative tumor size curve (AUC-log[RTS]) were used to evaluate the antitumor effect of the treatments. Results: Both SGD and AUC-log(RTS) values showed that 191Pt-cisplatin was significantly ( P < 0.05) more effective in retarding tumor growth than nonradioactive cisplatin. No differences in mortality between the different groups could be observed and no significant differences in weight change between the mice treated with cisplatin or 191Pt-cisplatin could be seen. Conclusion: 191Pt-cisplatin is a more effective drug than nonradioactive cisplatin in retarding tumor growth on nude mice without adding systemic toxic effects. We believe that radioactive cisplatin may prove to be an alternative to conventional cisplatin; however, the possible toxic effects on organs at risk have to be thoroughly investigated.