An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma

• Published in: Cell Vol. 147; no. 2; pp. 370 - 381
• Main Authors: Sumazin, Pavel, Yang, Xuerui, Chiu, Hua-Sheng, Chung, Wei-Jen, Iyer, Archana, Llobet-Navas, David, Rajbhandari, Presha, Bansal, Mukesh, Guarnieri, Paolo, Silva, Jose, Califano, Andrea
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.10.2011
• Subjects: cell growth; gene expression; Gene Expression Regulation, Neoplastic; genes; Glioblastoma - genetics; Glioblastoma - metabolism; Humans; loci; microRNA; MicroRNAs - metabolism; Multivariate Analysis; neoplasm cells; Oncogenes; PTEN Phosphohydrolase - genetics; RNA Interference; small interfering RNA

By analyzing gene expression data in glioblastoma in combination with matched microRNA profiles, we have uncovered a posttranscriptional regulation layer of surprising magnitude, comprising more than 248,000 microRNA (miR)-mediated interactions. These include ∼7,000 genes whose transcripts act as mi...