The Complete Genome Sequence of a Chronic Atrophic Gastritis Helicobacter pylori Strain: Evolution during Disease Progression

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 26; pp. 9999 - 10004
• Main Authors: Oh, Jung D., Kling-Bäckhed, Helene, Giannakis, Marios, Xu, Jian, Fulton, Robert S., Fulton, Lucinda A., Cordum, Holland S., Wang, Chunyan, Elliott, Glendoria, Edwards, Jennifer, Mardis, Elaine R., Engstrand, Lars G., Gordon, Jeffrey I.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.06.2006; National Acad Sciences
• Subjects: Adenocarcinoma; Adenocarcinoma - microbiology; Bacteria; Base Pairing; Biological Sciences; Biosynthesis; Cancer; Chronic Disease; Disease Progression; DNA; Enzymes; Epithelial cells; Gastritis, Atrophic - microbiology; Gastrointestinal diseases; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes; Genome, Bacterial - genetics; Genomes; Genomic Instability; Genomics; Genotype; Helicobacter pylori; Helicobacter pylori - drug effects; Helicobacter pylori - genetics; Helicobacter pylori - growth & development; Humans; Hydrogen-Ion Concentration; Medicin och hälsovetenskap; Membrane proteins; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Open reading frames; Pathology; Rodents; Sequence Analysis, DNA; Stomach Neoplasms - microbiology

Helicobacter pylori produces acute superficial gastritis in nearly all of its human hosts. However, a subset of individuals develops chronic atrophic gastritis (ChAG), a condition characterized in part by diminished numbers of acid-producing parietal cells and increased risk for development of gastr...