Ablation of 5-lipoxygenase mitigates pancreatic lesion development

• Published in: The Journal of surgical research Vol. 194; no. 2; pp. 481 - 487
• Main Authors: Knab, Lawrence M., MD, Schultz, Michelle, PhD, Principe, Daniel R., MS, Mascarinas, Windel E., BS, Gounaris, Elias, PhD, Munshi, Hidayatullah G., MD, Grippo, Paul J., PhD, Bentrem, David J., MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015
• Subjects: 5-Lipoxygenase; Animals; Arachidonate 5-Lipoxygenase - metabolism; Carcinoma, Pancreatic Ductal - enzymology; Carcinoma, Pancreatic Ductal - etiology; Cell Line, Tumor; Fatty Acids, Omega-6 - metabolism; Female; Humans; Inflammation; Leukotriene B4 - metabolism; Mast Cells - physiology; Mice, Inbred C57BL; Mice, Transgenic; Omega-6 fatty acids; Pancreatic cancer; Pancreatic Neoplasms - enzymology; Pancreatic Neoplasms - etiology; Surgery; Tumor Microenvironment; Omega-6 fatty acids; Inflammation; Pancreatic cancer; 5-Lipoxygenase

Abstract Background Pancreatic ductal adenocarcinoma (PDAC), which continues to have a dismal prognosis, is associated with a pronounced fibroinflammatory response. Inflammation in vivo can be mediated by 5-lipoxygenase (5LO), an enzyme that converts omega-6 fatty acids (FA) to eicosanoids, includin...