Neutrophil extracellular traps mediate the crosstalk between plaque microenvironment and unstable carotid plaque formation

• Published in: Experimental & molecular medicine Vol. 56; no. 8; pp. 1717 - 1735
• Main Authors: Cao, Yu, Chen, Minghui, Jiao, Xinyu, Li, Shuijie, Wang, Dong, Zhan, Yongxuan, Li, Jiaju, Hao, Zhongfei, Li, Qingbin, Liu, Yang, Feng, Yan, Li, Ruiyan, Wang, Hongjun, Liu, Mingli, Fu, Qiang, Li, Yongli
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2024; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 13; 14; 38; 631/114; 631/250; 631/337; 631/80; Arteries; Arteriosclerosis; Artificial intelligence; Atherosclerosis; Bioinformatics; Biomedical and Life Sciences; Biomedicine; Cardiovascular disease; Cell activation; Cellular Microenvironment; Disease prevention; Endothelial cells; Extracellular Traps - metabolism; Female; Heart attacks; Heart diseases; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Intercellular adhesion molecule 1; Leukocyte migration; Leukocytes (neutrophilic); Macrophages; Male; Medical Biochemistry; Microenvironments; Molecular Medicine; Molecular modelling; Neutrophils; Neutrophils - immunology; Neutrophils - metabolism; NF-kappa B - metabolism; NF-κB protein; Plaque, Atherosclerotic - metabolism; Plaque, Atherosclerotic - pathology; Plaques; Signal Transduction; Stem Cells; Toll-like receptors; Umbilical vein; Vascularization; 생화학; Beijing China; United States > US; China

The development of unstable carotid atherosclerotic plaques is associated with the induction of neutrophil extracellular traps (NETs) via the activation of diverse inflammatory mediators in the circulating bloodstream. However, the underlying mechanisms through which NETs influence the microenvironm...