CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism - Silva, Robert M.; Ries, Vincent; Oo, Tinmarla Frances; Yarygina, Olga; Jackson‐Lewis, Vernice; Ryu, Elizabeth J.; Lu, Phoebe D.; Marciniak, Stefan M.; Ron, David; Przedborski, Serge; Kholodilov, Nikolai; Greene, Lloyd A.; et al. (Journal of neurochemistry, 2005)
Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects; Animals; Animals, Newborn; apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Axotomy - methods; Behavior, Animal; Biological and medical sciences; Blotting, Northern - methods; Blotting, Western - methods; Cell Count - methods; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Dopamine - metabolism; endoplasmic reticulum stress; Female; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; Immunohistochemistry - methods; In Situ Hybridization - methods; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation - physiology; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neurotoxins; Neurotransmitters; Oxidation; oxidative stress; Oxidopamine - toxicity; Parkinson's disease; Parkinsonian Disorders - etiology; Parkinsonian Disorders - metabolism; Parkinsonian Disorders - pathology; Pregnancy; programmed cell death; Rats; Regulatory Factor X Transcription Factors; Reverse Transcriptase Polymerase Chain Reaction - methods; RNA, Messenger - genetics; RNA, Messenger - metabolism; substantia nigra; Substantia Nigra - growth & development; Substantia Nigra - pathology; Time Factors; Transcription Factor CHOP - deficiency; Transcription Factor CHOP - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Tyrosine 3-Monooxygenase - metabolism; Animal model; Oxidative stress; Parkinson's disease; Central nervous system; Tissue culture; Parkinson disease; Activation; endoplasmic reticulum stress; Degenerative disease; Transcription factor; programmed cell death; Nervous system diseases; substantia nigra; Catecholamine; Gene expression; Cerebral disorder; Parkinsonism; Toxin; Locus niger; Cell death; Central nervous system disease; Neurotoxin; Neurotransmitter; Dopaminergic neuron; Endoplasmic reticulum; Extrapyramidal syndrome; Apoptosis