miR-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2

• Published in: FEBS letters Vol. 588; no. 6; pp. 915 - 921
• Main Authors: Wang, Zhiqiang, Qiao, Qiao, Chen, Min, Li, Xianhua, Wang, Zhenjun, Liu, Chuanxin, Xie, Zongtao
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 18.03.2014
• Subjects: 3' Untranslated Regions; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - secondary; Aged; Apoptosis; Base Sequence; Binding Sites; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - secondary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Esophageal cancer; esophageal neoplasms; Esophageal Neoplasms - genetics; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - pathology; Female; Gene Expression Regulation, Neoplastic; genes; Humans; Invasion; luciferase; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miR-625; Neoplasm Invasiveness; Proliferation; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; RNA Interference; Sox2; SOXB1 Transcription Factors - genetics; SOXB1 Transcription Factors - metabolism; Western blotting; Sox2; Proliferation; miR-625; Invasion; Esophageal cancer

•Expression of miR-625 in EC specimens was significantly lower than in corresponding adjacent tissues.•Low expression of miR-625 positively correlated with the proliferation and invasion of EC cell lines in vitro.•Direct binding of miR-625 to the Sox2 3′ UTR was demonstrated.•miR-625 overexpression...