Scavenger receptor B1 post-translational modifications in Rett syndrome

• Published in: FEBS letters Vol. 587; no. 14; pp. 2199 - 2204
• Main Authors: Sticozzi, Claudia, Belmonte, Giuseppe, Pecorelli, Alessandra, Cervellati, Franco, Leoncini, Silvia, Signorini, Cinzia, Ciccoli, Lucia, De Felice, Claudio, Hayek, Joussef, Valacchi, Giuseppe
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 11.07.2013
• Subjects: 4-Hydroxynonenal; Adolescent; Adult; Aldehydes - metabolism; autism; blood lipids; Case-Control Studies; Cells, Cultured; Child; Cholesterol; Female; fibroblasts; Fibroblasts - metabolism; HDL; high density lipoprotein; Humans; immunohistochemistry; Lipid Peroxidation; Lipids - blood; Oxidative Stress; patients; Protein adducts; Rett Syndrome - metabolism; Scavenger Receptors, Class B - metabolism; Ubiquitination; Western blotting; Young Adult; Oxidative stress; HDL; Ubiquitination; Protein adducts; 4-Hydroxynonenal; Cholesterol

•Rett patients have an alterated plasma lipid profile.•SRB1 (HDL receptor) is low in Rett fibroblasts.•Rett fibroblasts have high level of HNE with formation of HNE–SRB1 adducts.•SRB1 is ubiquitinated. The modulation of the HDL receptor scavenger receptor B1 (SRB1) was evaluated in skin fibroblasts...