Simvastatin Prevents Angiotensin II–Induced Cardiac Alteration and Oxidative Stress

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 40; no. 2; pp. 142 - 147
• Main Authors: Delbosc, Sandrine, Cristol, Jean-Paul, Descomps, Bernard, Mimran, Albert, Jover, Bernard
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.08.2002; Hagerstown, MD Lippincott
• Subjects: Angiotensin II - pharmacology; Animals; Aorta, Thoracic - drug effects; Aorta, Thoracic - metabolism; Biological and medical sciences; Body Weight - drug effects; Creatinine - blood; Dose-Response Relationship, Drug; Eating - drug effects; General and cellular metabolism. Vitamins; Hydrogen Peroxide - metabolism; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Lipids - blood; Male; Medical sciences; Myocardium - metabolism; Myocardium - pathology; Neutrophils - cytology; Neutrophils - drug effects; Neutrophils - metabolism; Oxidative Stress - drug effects; Pharmacology. Drug treatments; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Simvastatin - pharmacology; Sodium - urine; Heart; Hypertension; Oxidative stress; Rat; Enzyme; Simvastatin; Peptide hormone; Rodentia; Enzyme inhibitor; Cardiovascular disease; Statin derivative; Prevention; Renin angiotensin system; Vertebrata; Chemotherapy; Mammalia; Heart disease; Animal; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Angiotensin II; Hypertrophy; Antilipemic agent

The influence of the HMG-CoA reductase inhibitor simvastatin was assessed on the cardiovascular alterations and production of free radicals associated with chronic angiotensin II (Ang II) infusion. Simvastatin (60 mg/kg per day PO) or placebo were given concomitantly for 10 days in Sprague-Dawley ra...