Meeting report and review: Immunological assays and correlates of protection for next‐generation influenza vaccines

• Published in: Influenza and other respiratory viruses Vol. 14; no. 2; pp. 237 - 243
• Main Authors: Krammer, Florian, Weir, Jerry P., Engelhardt, Othmar, Katz, Jacqueline M., Cox, Rebecca Jane
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2020; John Wiley and Sons Inc
• Subjects: Animals; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Avian flu; CD4; CD4-Positive T-Lymphocytes - immunology; CD8; CD8-Positive T-Lymphocytes - immunology; Clinical trials; correlates of protection; Correlation; Cytotoxicity; Enzymes; Health aspects; Hemagglutination Inhibition Tests; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Humans; Immunity, Mucosal; Immunoglobulins; Immunology; Infections; Influenza; Influenza A Virus, H1N1 Subtype - immunology; influenza vaccine; Influenza vaccines; Influenza Vaccines - biosynthesis; Influenza Vaccines - immunology; Influenza viruses; Influenza, Human - immunology; Influenza, Human - prevention & control; Laboratories; Models, Animal; mucosal immunity; Neuraminidase - blood; Neuraminidase - immunology; Original; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; Product development; Proteins; Respiratory diseases; Serologic Tests - methods; stalk antibodies; Studies; Vaccination; Vaccines; Viruses; influenza; HI; MN; correlates of protection; influenza vaccine; CD4; stalk antibodies; CD8; NI; mucosal immunity
• ISSN: 1750-2640; 1750-2659
• DOI: 10.1111/irv.12706

Background This report summarizes the discussions and conclusions from the “Immunological Assays and Correlates of Protection for Next‐Generation Influenza Vaccines” meeting which took place in Siena, Italy, from March 31, 2019, to April 2, 2019. Conclusions Furthermore, we review current correlates of protection against influenza virus infection and disease and their usefulness for the development of next generation broadly protective and universal influenza virus vaccines.