Successful treatment with dupilumab for mucus plugs in severe asthma

A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long‐acting beta‐2 agonists. Chest CT showed multiple mucous plugs with bronchie...

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Published inRespirology case reports Vol. 11; no. 1; pp. e01074 - n/a
Main Authors Anai, Moriyasu, Yoshida, Chieko, Izumi, Hiroki, Muramoto, Kei, Saruwatari, Koichi, Tomita, Yusuke, Ichiyasu, Hidenori, Sakagami, Takuro
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.01.2023
John Wiley & Sons, Inc
Wiley
Subjects
Airway management
Antibodies
Aspergillosis
Asthma
Case Report
Case Reports
Cytokines
dupilumab
Fungal infections
Medical imaging
Monoclonal antibodies
mucus plugs
severe asthma
Steroids
Tomography
mucus plugs
severe asthma
dupilumab
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Abstract A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long‐acting beta‐2 agonists. Chest CT showed multiple mucous plugs with bronchiectasis, but further examination found that he did not meet the diagnostic criteria for allergic bronchopulmonary aspergillosis. After starting dupilumab for his severe eosinophilic asthma, his asthma control improved without exacerbation. Furthermore, most mucus plugs disappeared on chest CT after 16 weeks from initiating dupilumab. This case suggests that dupilumab may be an effective treatment against mucus plugs associated with severe eosinophilic asthma. We report a case of severe asthma in which the introduction of dupilumab improved the mucus plugs in addition to asthma control.
AbstractList A 29-year-old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long-acting beta-2 agonists. Chest CT showed multiple mucous plugs with bronchiectasis, but further examination found that he did not meet the diagnostic criteria for allergic bronchopulmonary aspergillosis. After starting dupilumab for his severe eosinophilic asthma, his asthma control improved without exacerbation. Furthermore, most mucus plugs disappeared on chest CT after 16 weeks from initiating dupilumab. This case suggests that dupilumab may be an effective treatment against mucus plugs associated with severe eosinophilic asthma.
A 29-year-old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long-acting beta-2 agonists. Chest CT showed multiple mucous plugs with bronchiectasis, but further examination found that he did not meet the diagnostic criteria for allergic bronchopulmonary aspergillosis. After starting dupilumab for his severe eosinophilic asthma, his asthma control improved without exacerbation. Furthermore, most mucus plugs disappeared on chest CT after 16 weeks from initiating dupilumab. This case suggests that dupilumab may be an effective treatment against mucus plugs associated with severe eosinophilic asthma.A 29-year-old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long-acting beta-2 agonists. Chest CT showed multiple mucous plugs with bronchiectasis, but further examination found that he did not meet the diagnostic criteria for allergic bronchopulmonary aspergillosis. After starting dupilumab for his severe eosinophilic asthma, his asthma control improved without exacerbation. Furthermore, most mucus plugs disappeared on chest CT after 16 weeks from initiating dupilumab. This case suggests that dupilumab may be an effective treatment against mucus plugs associated with severe eosinophilic asthma.
Abstract A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long‐acting beta‐2 agonists. Chest CT showed multiple mucous plugs with bronchiectasis, but further examination found that he did not meet the diagnostic criteria for allergic bronchopulmonary aspergillosis. After starting dupilumab for his severe eosinophilic asthma, his asthma control improved without exacerbation. Furthermore, most mucus plugs disappeared on chest CT after 16 weeks from initiating dupilumab. This case suggests that dupilumab may be an effective treatment against mucus plugs associated with severe eosinophilic asthma.
A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long‐acting beta‐2 agonists. Chest CT showed multiple mucous plugs with bronchiectasis, but further examination found that he did not meet the diagnostic criteria for allergic bronchopulmonary aspergillosis. After starting dupilumab for his severe eosinophilic asthma, his asthma control improved without exacerbation. Furthermore, most mucus plugs disappeared on chest CT after 16 weeks from initiating dupilumab. This case suggests that dupilumab may be an effective treatment against mucus plugs associated with severe eosinophilic asthma. We report a case of severe asthma in which the introduction of dupilumab improved the mucus plugs in addition to asthma control.
A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months, although he used a high dose of inhaled corticosteroids and a long‐acting beta‐2 agonists. Chest CT showed multiple mucous plugs with bronchiectasis, but further examination found that he did not meet the diagnostic criteria for allergic bronchopulmonary aspergillosis. After starting dupilumab for his severe eosinophilic asthma, his asthma control improved without exacerbation. Furthermore, most mucus plugs disappeared on chest CT after 16 weeks from initiating dupilumab. This case suggests that dupilumab may be an effective treatment against mucus plugs associated with severe eosinophilic asthma.
Author Anai, Moriyasu
Muramoto, Kei
Saruwatari, Koichi
Izumi, Hiroki
Sakagami, Takuro
Yoshida, Chieko
Ichiyasu, Hidenori
Tomita, Yusuke
AuthorAffiliation 1 Department of Respiratory Medicine, Faculty of Life Sciences Kumamoto University Kumamoto Japan
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  surname: Sakagami
  fullname: Sakagami, Takuro
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36540290$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1164/rccm.202110-2265OC
10.1172/JCI95693
10.1172/JCI84910
10.1136/thoraxjnl-2019-213415
10.1513/AnnalsATS.201807-485AW
ContentType Journal Article
Copyright 2022 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
2022 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
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Issue 1
Keywords mucus plugs
severe asthma
dupilumab
Language English
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2022 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
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Snippet A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months,...
A 29-year-old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months,...
A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months,...
A 29-year-old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or 2 months,...
Abstract A 29‐year‐old man presented to our hospital with severe eosinophilic asthma. He needed a short OCS burst for exacerbation of asthma once every 1 or...
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SubjectTerms Airway management
Antibodies
Aspergillosis
Asthma
Case Report
Case Reports
Cytokines
dupilumab
Fungal infections
Medical imaging
Monoclonal antibodies
mucus plugs
severe asthma
Steroids
Tomography
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Title Successful treatment with dupilumab for mucus plugs in severe asthma
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Frcr2.1074
https://www.ncbi.nlm.nih.gov/pubmed/36540290
https://www.proquest.com/docview/2758219778
https://www.proquest.com/docview/2756672596
https://pubmed.ncbi.nlm.nih.gov/PMC9752256
https://doaj.org/article/8960c2f29f884a9a9c2ee3f584b99d57
Volume 11
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