Modeling the Association between 43 Different Clinical and Pathological Variables and the Severity of Cognitive Impairment in a Large Autopsy Cohort of Elderly Persons

• Published in: Brain pathology (Zurich, Switzerland) Vol. 20; no. 1; pp. 66 - 79
• Main Authors: Nelson, Peter T., Abner, Erin L., Schmitt, Frederick A., Kryscio, Richard J., Jicha, Gregory A., Smith, Charles D., Davis, Daron G., Poduska, John W., Patel, Ela, Mendiondo, Marta S., Markesbery, William R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2010
• Subjects: Aged; Aged, 80 and over; Aging - pathology; Aging - psychology; Alzheimer Disease - pathology; ApoE; Apolipoproteins E - metabolism; Autopsy; Brain - pathology; Cerebral Cortex - pathology; cognition; Cognition Disorders - pathology; Cognition Disorders - psychology; Cohort Studies; Databases, Factual; DLB; DNA-Binding Proteins - metabolism; Female; hippocampal sclerosis; Hippocampus - pathology; human; Humans; Immunohistochemistry; Linear Models; Male; Models, Statistical; Neuropsychological Tests; stroke

We evaluated the association between mini‐mental status examination (MMSE) scores proximal to death and the values of 43 different clinical and pathological parameters. Studies were performed using data from 334 elderly, longitudinally evaluated research subjects who had undergone autopsy and satisf...