Tyramine-Mediated Activation of Sympathetic Nerves Inhibits Insulin Secretion in Humans

• Published in: The journal of clinical endocrinology and metabolism Vol. 92; no. 10; pp. 4035 - 4038
• Main Authors: Gilliam, Lisa K., Palmer, Jerry P., Taborsky, Gerald J.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.10.2007; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adolescent; Adult; Arginine - administration & dosage; Beta cells; Biological and medical sciences; Blood pressure; Blood Pressure - drug effects; Cell activation; Electrical stimuli; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Human subjects; Humans; Hypotheses; Insulin; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - metabolism; Male; Medical sciences; Norepinephrine; Norepinephrine - blood; Physiology; Sympathetic nerves; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - physiology; Sympathomimetics - administration & dosage; Tyramine; Tyramine - administration & dosage; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Sympathetic nerve; Tyramine; Obesity; Nutrition; Insulin human; Secretion; Nutrition disorder; Metabolic diseases; Activation; Sympathomimetic; Inhibitor; Endocrinology; Nutritional status

Context: Older studies have shown that high doses of norepinephrine infused into human subjects can inhibit insulin secretion. Similar inhibition during electrical stimulation of sympathetic nerves in animals raises the possibility that the suppression of insulin secretion seen in humans could refle...