Genetic association between intronic variants in AS3MT and arsenic methylation efficiency is focused on a large linkage disequilibrium cluster in chromosome 10

• Published in: Journal of applied toxicology Vol. 30; no. 3; pp. 260 - 270
• Main Authors: Gomez-Rubio, Paulina, Meza-Montenegro, Maria M., Cantu-Soto, Ernesto, Klimecki, Walter T.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.04.2010
• Subjects: 5'-Nucleotidase - genetics; Arsenic; Arsenic - metabolism; Arsenic - urine; Arsenic Poisoning - genetics; Arsenic Poisoning - urine; Arsenicals - urine; AS3MT; Chromosomes; Chromosomes, Human, Pair 10 - genetics; Clusters; Female; Genes; Genetic Association Studies; Genetics; Humans; Introns - genetics; Linkage Disequilibrium; Male; Metabolism; Methylation; Methyltransferases - genetics; Mexico; Mouth Mucosa - metabolism; Multigene Family; Polymorphism; Polymorphism, Single Nucleotide; SNP; Steroid 17-alpha-Hydroxylase - genetics; Mexico; AS3MT; polymorphism; Arsenic; SNP; Linkage Disequilibrium
• ISSN: 0260-437X; 1099-1263; 1099-1263
• DOI: 10.1002/jat.1492

Differences in arsenic metabolism are known to play a role in individual variability in arsenic‐induced disease susceptibility. Genetic variants in genes relevant to arsenic metabolism are considered to be partially responsible for the variation in arsenic metabolism. Specifically, variants in arsen...