A literature review of liver function test elevations in rifampin drug–drug interaction studies

• Published in: Clinical and translational science Vol. 15; no. 7; pp. 1561 - 1580
• Main Authors: Ibrahim, Sherry M., Pithavala, Yazdi K., Vourvahis, Manoli, Chen, Joseph
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.07.2022; John Wiley and Sons Inc; Wiley
• Subjects: Antiretroviral drugs; Atazanavir; Cancer therapies; Complications and side effects; Darunavir; Drug dosages; Drug interaction; Drug interactions; Efavirenz; Enzymes; Hepatotoxicity; Literature reviews; Liver; Liver diseases; Medical research; Medicine, Experimental; Metabolic activation; Metabolic rate; Metabolism; Metabolites; Proteases; Proteinase inhibitors; Review; Reviews; Rifampin; Ritonavir; RNA polymerase; Saquinavir; United States > US

Although rifampin drug–drug interaction (DDI) studies are routinely conducted, there have been instances of liver function test (LFT) elevations, warranting further evaluation. A literature review was conducted to identify studies in which combination with rifampin resulted in hepatic events and eva...