Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques - Rosati, Margherita; Agarwal, Mahesh; Hu, Xintao; Devasundaram, Santhi; Stellas, Dimitris; Chowdhury, Bhabadeb; Bear, Jenifer; Burns, Robert; Donohue, Duncan; Pessaint, Laurent; Andersen, Hanne; Lewis, Mark G.; et al. (PLoS pathogens, 2021)
Keywords: Animal models; Animals; Antibodies; Antigens; Binding; Biology and Life Sciences; Clinical trials; Cohort Studies; COVID-19; COVID-19 - immunology; COVID-19 - therapy; Deoxyribonucleic acid; Disease Models, Animal; DNA; DNA vaccines; DNA, Viral - immunology; Electroporation; Female; Health aspects; HIV; Human immunodeficiency virus; Immune response; Immune response (cell-mediated); Immune response (humoral); Immune system; Immunization; Immunization, Passive; Immunogenicity; Immunological research; Infections; Leukocytes, Mononuclear - immunology; Lymphocytes; Lymphocytes T; Macaca mulatta; Medicine and Health Sciences; Mice; mRNA; Mucosa; Mutation; Neutralizing; Phagocytosis; Plasmids; Proteins; Research and Analysis Methods; Respiratory tract; Response rates; RNA, Messenger - analysis; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; T-Lymphocytes - immunology; Trachea; Vaccines; Vaccines, DNA - administration & dosage; Vaccines, DNA - immunology; Variance analysis; Vectors (Biology); Viral diseases; Viral proteins; Viruses; United States; United States--US