Structural core of the executive control network: A high angular resolution diffusion MRI study
Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivi...
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Published in | Human brain mapping Vol. 41; no. 5; pp. 1226 - 1236 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Hoboken, USA
John Wiley & Sons, Inc
01.04.2020
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Abstract | Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high‐angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly‐connected “structural core” of the ECN comprising three components: interhemispheric frontal connections, a fronto‐parietal subnetwork and fronto‐striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post‐hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour. |
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AbstractList | Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high‐angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly‐connected “structural core” of the ECN comprising three components: interhemispheric frontal connections, a fronto‐parietal subnetwork and fronto‐striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post‐hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour. Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high-angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly-connected "structural core" of the ECN comprising three components: interhemispheric frontal connections, a fronto-parietal subnetwork and fronto-striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post-hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour.Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high-angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly-connected "structural core" of the ECN comprising three components: interhemispheric frontal connections, a fronto-parietal subnetwork and fronto-striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post-hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour. Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high‐angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort ( n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly‐connected “structural core” of the ECN comprising three components: interhemispheric frontal connections, a fronto‐parietal subnetwork and fronto‐striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance ( p = .003). Post‐hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour. |
Audience | Academic |
Author | Burnham, Samantha Grieve, Stuart M. Sutherland, Greg T. Shen, Kai‐kai McCorkindale, Andrew N. Lyon, Matthew Fripp, Jurgen Martins, Ralph Welton, Thomas |
AuthorAffiliation | 5 Department of Radiology Royal Prince Alfred Hospital Sydney New South Wales Australia 1 Australian eHealth Research Centre CSIRO Floreat Western Australia Australia 3 Sydney Translational Imaging Laboratory Heart Research Institute, Charles Perkins Centre, University of Sydney Sydney New South Wales Australia 4 Faculty of Medicine and Health Charles Perkins Centre and School of Medical Sciences, University of Sydney Sydney New South Wales Australia 2 Department of Biomedical Sciences Macquarie University Sydney New South Wales Australia |
AuthorAffiliation_xml | – name: 5 Department of Radiology Royal Prince Alfred Hospital Sydney New South Wales Australia – name: 1 Australian eHealth Research Centre CSIRO Floreat Western Australia Australia – name: 2 Department of Biomedical Sciences Macquarie University Sydney New South Wales Australia – name: 3 Sydney Translational Imaging Laboratory Heart Research Institute, Charles Perkins Centre, University of Sydney Sydney New South Wales Australia – name: 4 Faculty of Medicine and Health Charles Perkins Centre and School of Medical Sciences, University of Sydney Sydney New South Wales Australia |
Author_xml | – sequence: 1 givenname: Kai‐kai orcidid: 0000-0002-5956-501X surname: Shen fullname: Shen, Kai‐kai organization: Heart Research Institute, Charles Perkins Centre, University of Sydney – sequence: 2 givenname: Thomas surname: Welton fullname: Welton, Thomas organization: Heart Research Institute, Charles Perkins Centre, University of Sydney – sequence: 3 givenname: Matthew surname: Lyon fullname: Lyon, Matthew organization: Heart Research Institute, Charles Perkins Centre, University of Sydney – sequence: 4 givenname: Andrew N. surname: McCorkindale fullname: McCorkindale, Andrew N. organization: Heart Research Institute, Charles Perkins Centre, University of Sydney – sequence: 5 givenname: Greg T. surname: Sutherland fullname: Sutherland, Greg T. organization: Charles Perkins Centre and School of Medical Sciences, University of Sydney – sequence: 6 givenname: Samantha surname: Burnham fullname: Burnham, Samantha organization: CSIRO – sequence: 7 givenname: Jurgen surname: Fripp fullname: Fripp, Jurgen organization: CSIRO – sequence: 8 givenname: Ralph surname: Martins fullname: Martins, Ralph organization: Macquarie University – sequence: 9 givenname: Stuart M. orcidid: 0000-0002-2712-157X surname: Grieve fullname: Grieve, Stuart M. email: stuart.grieve@sydney.edu.au organization: Royal Prince Alfred Hospital |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31765057$$D View this record in MEDLINE/PubMed |
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Copyright | 2019 The Authors. published by Wiley Periodicals, Inc. 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. COPYRIGHT 2019 John Wiley & Sons, Inc. 2019. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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Snippet | Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and... |
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SubjectTerms | Aging Angular resolution Cerebral hemispheres Cognition Cognitive ability Executive function Magnetic resonance imaging Neostriatum Neural networks Nodes Prefrontal cortex Substantia alba |
Title | Structural core of the executive control network: A high angular resolution diffusion MRI study |
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