Structural core of the executive control network: A high angular resolution diffusion MRI study

Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivi...

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Published inHuman brain mapping Vol. 41; no. 5; pp. 1226 - 1236
Main Authors Shen, Kai‐kai, Welton, Thomas, Lyon, Matthew, McCorkindale, Andrew N., Sutherland, Greg T., Burnham, Samantha, Fripp, Jurgen, Martins, Ralph, Grieve, Stuart M.
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.04.2020
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Abstract Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high‐angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly‐connected “structural core” of the ECN comprising three components: interhemispheric frontal connections, a fronto‐parietal subnetwork and fronto‐striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post‐hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour.
AbstractList Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high‐angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly‐connected “structural core” of the ECN comprising three components: interhemispheric frontal connections, a fronto‐parietal subnetwork and fronto‐striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post‐hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour.
Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high-angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly-connected "structural core" of the ECN comprising three components: interhemispheric frontal connections, a fronto-parietal subnetwork and fronto-striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post-hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour.Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high-angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort (n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly-connected "structural core" of the ECN comprising three components: interhemispheric frontal connections, a fronto-parietal subnetwork and fronto-striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance (p = .003). Post-hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour.
Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and neurodegenerative conditions. Underpinning EF performance are functional nodes in the executive control network (ECN), while the structural connectivity underlying this network is not well understood. In this paper, we evaluated the structural white matter tracts that interconnect the ECN and investigated their relationship to the EF performance. Using high‐angular resolution diffusion MRI data, we performed tractography analysis of structural connectivity in a cognitively normal cohort ( n = 140), specifically targeting the connectivity between ECN nodes. Our data revealed the presence of a strongly‐connected “structural core” of the ECN comprising three components: interhemispheric frontal connections, a fronto‐parietal subnetwork and fronto‐striatal connections between right dorsolateral prefrontal cortex and right caudate. These pathways were strongly correlated with EF performance ( p = .003). Post‐hoc analysis of subregions within the significant ECN connections showed that these effects were driven by a highly specific subset of interconnected cortical regions. The structural core subnetwork of the functional ECN may be an important feature crucial to a better future understanding of human cognition and behaviour.
Audience Academic
Author Burnham, Samantha
Grieve, Stuart M.
Sutherland, Greg T.
Shen, Kai‐kai
McCorkindale, Andrew N.
Lyon, Matthew
Fripp, Jurgen
Martins, Ralph
Welton, Thomas
AuthorAffiliation 5 Department of Radiology Royal Prince Alfred Hospital Sydney New South Wales Australia
1 Australian eHealth Research Centre CSIRO Floreat Western Australia Australia
3 Sydney Translational Imaging Laboratory Heart Research Institute, Charles Perkins Centre, University of Sydney Sydney New South Wales Australia
4 Faculty of Medicine and Health Charles Perkins Centre and School of Medical Sciences, University of Sydney Sydney New South Wales Australia
2 Department of Biomedical Sciences Macquarie University Sydney New South Wales Australia
AuthorAffiliation_xml – name: 5 Department of Radiology Royal Prince Alfred Hospital Sydney New South Wales Australia
– name: 1 Australian eHealth Research Centre CSIRO Floreat Western Australia Australia
– name: 2 Department of Biomedical Sciences Macquarie University Sydney New South Wales Australia
– name: 3 Sydney Translational Imaging Laboratory Heart Research Institute, Charles Perkins Centre, University of Sydney Sydney New South Wales Australia
– name: 4 Faculty of Medicine and Health Charles Perkins Centre and School of Medical Sciences, University of Sydney Sydney New South Wales Australia
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  organization: Royal Prince Alfred Hospital
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Snippet Executive function (EF) is a set of cognitive capabilities considered essential for successful daily living, and is negatively affected by ageing and...
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SubjectTerms Aging
Angular resolution
Cerebral hemispheres
Cognition
Cognitive ability
Executive function
Magnetic resonance imaging
Neostriatum
Neural networks
Nodes
Prefrontal cortex
Substantia alba
Title Structural core of the executive control network: A high angular resolution diffusion MRI study
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhbm.24870
https://www.ncbi.nlm.nih.gov/pubmed/31765057
https://www.proquest.com/docview/2370431920
https://www.proquest.com/docview/2317958344
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Volume 41
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