Cancer Pharmacogenomics: Early Promise, But Concerted Effort Needed

• Published in: Science (American Association for the Advancement of Science) Vol. 339; no. 6127; pp. 1563 - 1566
• Main Author: McLeod, Howard L.
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 29.03.2013; The American Association for the Advancement of Science
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Biology; Biomarkers, Pharmacological; Biomarkers, Tumor - genetics; Breast cancer; Cancer; Clinical trials; DNA; Dosing; Drug Design; Drugs; Female; Genetic Markers; Genetic mutation; Genome, Human; Genomics; Germ-Line Mutation; Humans; Molecular Targeted Therapy; Mutations; Neoplasms - drug therapy; Neoplasms - genetics; Oncology; Patients; Pharmaceutical sciences; Pharmacogenetics; REVIEWS; Sequencing; Side effects; Somatic mutation; Tumors

The past decade has brought together substantial advances in human genome analysis and a maturation of understanding of tumor biology. Although there is much progress still to be made, there are now several prominent examples in which tumor-associated somatic mutations have been used to identify cel...