Variable Lymphocyte Receptor Recognition of the Immunodominant Glycoprotein of Bacillus anthracis Spores

• Published in: Structure (London) Vol. 20; no. 3; pp. 479 - 486
• Main Authors: Kirchdoerfer, Robert N., Herrin, Brantley R., Han, Byung Woo, Turnbough, Charles L., Cooper, Max D., Wilson, Ian A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.03.2012
• Subjects: Animals; Bacillus anthracis; Bacillus anthracis - chemistry; Cloning, Molecular; Crystallography; Glycoproteins - chemistry; Glycoproteins - metabolism; Immunodominant Epitopes - chemistry; Immunodominant Epitopes - metabolism; Lampreys - immunology; Models, Molecular; Mutagenesis; Protein Binding; Receptors, Immunologic - chemistry; Spores, Bacterial - chemistry

Variable lymphocyte receptors (VLRs) are the adaptive immune receptors of jawless fish, which evolved adaptive immunity independent of other vertebrates. In lieu of the immunoglobulin fold-based T and B cell receptors, lymphocyte-like cells of jawless fish express VLRs (VLRA, VLRB, or VLRC) composed...