Noninvasive Treatment of Deep Venous Thrombosis Using Pulsed Ultrasound Cavitation Therapy (Histotripsy) in a Porcine Model

• Published in: Journal of vascular and interventional radiology Vol. 22; no. 3; pp. 369 - 377
• Main Authors: Maxwell, Adam D., MS, Owens, Gabe, MD, PhD, Gurm, Hitinder S., MD, Ives, Kimberly, DVM, Myers, Daniel D., DVM, MPH, Xu, Zhen, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2011
• Subjects: Animals; Disease Models, Animal; Feasibility Studies; Femoral Vein - diagnostic imaging; Femoral Vein - pathology; Femoral Vein - physiopathology; High-Intensity Focused Ultrasound Ablation - instrumentation; Radiology; Regional Blood Flow; Swine; Transducers; Ultrasonography, Doppler, Color; Ultrasonography, Interventional; Vascular Patency; Venous Thrombosis - diagnostic imaging; Venous Thrombosis - pathology; Venous Thrombosis - physiopathology; Venous Thrombosis - therapy; APTT; 2D; two dimensional; ACT; DVT; deep vein thrombosis; activated partial thromboplastin time; spatial peak temporal average intensity; activated clotting time; I spta; I sppa; spatial peak pulse average intensity

Abstract Purpose This study evaluated histotripsy as a noninvasive, image-guided method of thrombolysis in a porcine model of deep vein thrombosis. Histotripsy therapy uses short, high-intensity, focused ultrasound pulses to cause mechanical breakdown of targeted soft tissue by acoustic cavitation,...