Noninvasive Treatment of Deep Venous Thrombosis Using Pulsed Ultrasound Cavitation Therapy (Histotripsy) in a Porcine Model

Abstract Purpose This study evaluated histotripsy as a noninvasive, image-guided method of thrombolysis in a porcine model of deep vein thrombosis. Histotripsy therapy uses short, high-intensity, focused ultrasound pulses to cause mechanical breakdown of targeted soft tissue by acoustic cavitation,...

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Published inJournal of vascular and interventional radiology Vol. 22; no. 3; pp. 369 - 377
Main Authors Maxwell, Adam D., MS, Owens, Gabe, MD, PhD, Gurm, Hitinder S., MD, Ives, Kimberly, DVM, Myers, Daniel D., DVM, MPH, Xu, Zhen, PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2011
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Abstract Abstract Purpose This study evaluated histotripsy as a noninvasive, image-guided method of thrombolysis in a porcine model of deep vein thrombosis. Histotripsy therapy uses short, high-intensity, focused ultrasound pulses to cause mechanical breakdown of targeted soft tissue by acoustic cavitation, which is guided by real-time ultrasound imaging. This is an in vivo feasibility study of histotripsy thrombolysis. Methods and Materials Acute thrombi were formed in the femoral vein of juvenile pigs weighing 30–40 kg by balloon occlusion with two catheters and thrombin infusion. A 10-cm-diameter 1-MHz focused transducer was used for therapy. An 8-MHz ultrasound imager was used to align the clot with the therapy focus. Therapy consisted of five cycle pulses delivered at a rate of 1 kHz and peak negative pressure between 14 and 19 MPa. The focus was scanned along the long axis of the vessel to treat the entire visible clot during ultrasound exposure. The targeted region identified by a hyperechoic cavitation bubble cloud was visualized via ultrasound during treatment. Results Thrombus breakdown was apparent as a decrease in echogenicity within the vessel in 10 of 12 cases and in 7 cases improved flow through the vein as measured by color Doppler. Vessel histology found denudation of vascular endothelium and small pockets of hemorrhage in the vessel adventitia and underlying muscle and fatty tissue, but perforation of the vessel wall was never observed. Conclusions The results indicate histotripsy has potential for development as a noninvasive treatment for deep vein thrombosis.
AbstractList This study evaluated histotripsy as a noninvasive, image-guided method of thrombolysis in a porcine model of deep vein thrombosis. Histotripsy therapy uses short, high-intensity, focused ultrasound pulses to cause mechanical breakdown of targeted soft tissue by acoustic cavitation, which is guided by real-time ultrasound imaging. This is an in vivo feasibility study of histotripsy thrombolysis. Acute thrombi were formed in the femoral vein of juvenile pigs weighing 30-40 kg by balloon occlusion with two catheters and thrombin infusion. A 10-cm-diameter 1-MHz focused transducer was used for therapy. An 8-MHz ultrasound imager was used to align the clot with the therapy focus. Therapy consisted of five cycle pulses delivered at a rate of 1 kHz and peak negative pressure between 14 and 19 MPa. The focus was scanned along the long axis of the vessel to treat the entire visible clot during ultrasound exposure. The targeted region identified by a hyperechoic cavitation bubble cloud was visualized via ultrasound during treatment. Thrombus breakdown was apparent as a decrease in echogenicity within the vessel in 10 of 12 cases and in 7 cases improved flow through the vein as measured by color Doppler. Vessel histology found denudation of vascular endothelium and small pockets of hemorrhage in the vessel adventitia and underlying muscle and fatty tissue, but perforation of the vessel wall was never observed. The results indicate histotripsy has potential for development as a noninvasive treatment for deep vein thrombosis.
Abstract Purpose This study evaluated histotripsy as a noninvasive, image-guided method of thrombolysis in a porcine model of deep vein thrombosis. Histotripsy therapy uses short, high-intensity, focused ultrasound pulses to cause mechanical breakdown of targeted soft tissue by acoustic cavitation, which is guided by real-time ultrasound imaging. This is an in vivo feasibility study of histotripsy thrombolysis. Methods and Materials Acute thrombi were formed in the femoral vein of juvenile pigs weighing 30–40 kg by balloon occlusion with two catheters and thrombin infusion. A 10-cm-diameter 1-MHz focused transducer was used for therapy. An 8-MHz ultrasound imager was used to align the clot with the therapy focus. Therapy consisted of five cycle pulses delivered at a rate of 1 kHz and peak negative pressure between 14 and 19 MPa. The focus was scanned along the long axis of the vessel to treat the entire visible clot during ultrasound exposure. The targeted region identified by a hyperechoic cavitation bubble cloud was visualized via ultrasound during treatment. Results Thrombus breakdown was apparent as a decrease in echogenicity within the vessel in 10 of 12 cases and in 7 cases improved flow through the vein as measured by color Doppler. Vessel histology found denudation of vascular endothelium and small pockets of hemorrhage in the vessel adventitia and underlying muscle and fatty tissue, but perforation of the vessel wall was never observed. Conclusions The results indicate histotripsy has potential for development as a noninvasive treatment for deep vein thrombosis.
PURPOSEThis study evaluated histotripsy as a noninvasive, image-guided method of thrombolysis in a porcine model of deep vein thrombosis. Histotripsy therapy uses short, high-intensity, focused ultrasound pulses to cause mechanical breakdown of targeted soft tissue by acoustic cavitation, which is guided by real-time ultrasound imaging. This is an in vivo feasibility study of histotripsy thrombolysis. METHODS AND MATERIALSAcute thrombi were formed in the femoral vein of juvenile pigs weighing 30-40 kg by balloon occlusion with two catheters and thrombin infusion. A 10-cm-diameter 1-MHz focused transducer was used for therapy. An 8-MHz ultrasound imager was used to align the clot with the therapy focus. Therapy consisted of five cycle pulses delivered at a rate of 1 kHz and peak negative pressure between 14 and 19 MPa. The focus was scanned along the long axis of the vessel to treat the entire visible clot during ultrasound exposure. The targeted region identified by a hyperechoic cavitation bubble cloud was visualized via ultrasound during treatment. RESULTSThrombus breakdown was apparent as a decrease in echogenicity within the vessel in 10 of 12 cases and in 7 cases improved flow through the vein as measured by color Doppler. Vessel histology found denudation of vascular endothelium and small pockets of hemorrhage in the vessel adventitia and underlying muscle and fatty tissue, but perforation of the vessel wall was never observed. CONCLUSIONSThe results indicate histotripsy has potential for development as a noninvasive treatment for deep vein thrombosis.
Author Gurm, Hitinder S., MD
Owens, Gabe, MD, PhD
Ives, Kimberly, DVM
Maxwell, Adam D., MS
Xu, Zhen, PhD
Myers, Daniel D., DVM, MPH
AuthorAffiliation Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA
Department of Pediatric Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA
Department of Vascular Surgery, University of Michigan, Ann Arbor, MI, 48109, USA
AuthorAffiliation_xml – name: Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA
– name: Department of Pediatric Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA
– name: Department of Vascular Surgery, University of Michigan, Ann Arbor, MI, 48109, USA
– name: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA
Author_xml – sequence: 1
  fullname: Maxwell, Adam D., MS
– sequence: 2
  fullname: Owens, Gabe, MD, PhD
– sequence: 3
  fullname: Gurm, Hitinder S., MD
– sequence: 4
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– sequence: 5
  fullname: Myers, Daniel D., DVM, MPH
– sequence: 6
  fullname: Xu, Zhen, PhD
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21194969$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords APTT
2D
two dimensional
ACT
DVT
deep vein thrombosis
activated partial thromboplastin time
spatial peak temporal average intensity
activated clotting time
I spta
I sppa
spatial peak pulse average intensity
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Snippet Abstract Purpose This study evaluated histotripsy as a noninvasive, image-guided method of thrombolysis in a porcine model of deep vein thrombosis. Histotripsy...
This study evaluated histotripsy as a noninvasive, image-guided method of thrombolysis in a porcine model of deep vein thrombosis. Histotripsy therapy uses...
PURPOSEThis study evaluated histotripsy as a noninvasive, image-guided method of thrombolysis in a porcine model of deep vein thrombosis. Histotripsy therapy...
SourceID pubmedcentral
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SubjectTerms Animals
Disease Models, Animal
Feasibility Studies
Femoral Vein - diagnostic imaging
Femoral Vein - pathology
Femoral Vein - physiopathology
High-Intensity Focused Ultrasound Ablation - instrumentation
Radiology
Regional Blood Flow
Swine
Transducers
Ultrasonography, Doppler, Color
Ultrasonography, Interventional
Vascular Patency
Venous Thrombosis - diagnostic imaging
Venous Thrombosis - pathology
Venous Thrombosis - physiopathology
Venous Thrombosis - therapy
Title Noninvasive Treatment of Deep Venous Thrombosis Using Pulsed Ultrasound Cavitation Therapy (Histotripsy) in a Porcine Model
URI https://www.clinicalkey.es/playcontent/1-s2.0-S1051044310010055
https://dx.doi.org/10.1016/j.jvir.2010.10.007
https://www.ncbi.nlm.nih.gov/pubmed/21194969
https://search.proquest.com/docview/854379814
https://pubmed.ncbi.nlm.nih.gov/PMC3053086
Volume 22
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